skin Flashcards
epidermal appendages
hair follicles, nails, sweat glands, sebaceous glands
epidermis
avascular component of the skin
keratinised, stratified squamous epithelium with basil laminar
epidermal thickness
thick skin 1mm, thin skin 0.1mm
5 strata of skin
- stratum basale
- stratum spinousum
- stratum granulosum
- stratum lucidum
- stratum corneum
stratum basale cells
columnar shaped epidermal stem cells
stratum basale basal laminar
interfaces with the dermis
rete ridge
epidermis invaginating into the dermis
cells in stratum basal
melanocytes and Merkel cells
Merkel cells
attach to non myelinated nerve ending, mechanoreceptor sensitive to light touch - mostly in thick skin
melanocytes
have a space around them
stratum spinosum cells
intracellular spinous cytoplasmic projections
desmosomes
cell to cell adhesions, resistant to shear stress
cells I stratum spinonosum
langerhans cells
- also present in papillary dermis
langerhans cells
dendritic antigen presenting cells
in stratum spinous, cell begin to
flatten and produce water proofing glycolipid - lammellar bodies
keratohyalin granules
and accumulate tonofilaments
monofilaments
intracellular connector components
stratum granulosum cells
squamous keratinocytes
2-3 layers
what’s in stratum granulosum
more lamellar bodies and keratinohyaline granules
dehydrate the cells
what happens at the stratum granulosum
cells begin to die
due to dehydration and not vascularised
what happens when the cells die
lamellar Bodies are released, keratinohyaline granules fuse with monofilaments and form cross linked keratin
keratin
tight water proof layer
UV protection and pH stabilisation
stratum lucidum
only in thick skin
dead cell layer
several flattened cells thick and rich in eleidin