skin Flashcards

1
Q

epidermal appendages

A

hair follicles, nails, sweat glands, sebaceous glands

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2
Q

epidermis

A

avascular component of the skin

keratinised, stratified squamous epithelium with basil laminar

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3
Q

epidermal thickness

A

thick skin 1mm, thin skin 0.1mm

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4
Q

5 strata of skin

A
  1. stratum basale
  2. stratum spinousum
  3. stratum granulosum
  4. stratum lucidum
  5. stratum corneum
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5
Q

stratum basale cells

A

columnar shaped epidermal stem cells

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6
Q

stratum basale basal laminar

A

interfaces with the dermis

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7
Q

rete ridge

A

epidermis invaginating into the dermis

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8
Q

cells in stratum basal

A

melanocytes and Merkel cells

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9
Q

Merkel cells

A

attach to non myelinated nerve ending, mechanoreceptor sensitive to light touch - mostly in thick skin

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10
Q

melanocytes

A

have a space around them

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11
Q

stratum spinosum cells

A

intracellular spinous cytoplasmic projections

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12
Q

desmosomes

A

cell to cell adhesions, resistant to shear stress

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13
Q

cells I stratum spinonosum

A

langerhans cells

- also present in papillary dermis

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14
Q

langerhans cells

A

dendritic antigen presenting cells

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15
Q

in stratum spinous, cell begin to

A

flatten and produce water proofing glycolipid - lammellar bodies
keratohyalin granules
and accumulate tonofilaments

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16
Q

monofilaments

A

intracellular connector components

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17
Q

stratum granulosum cells

A

squamous keratinocytes

2-3 layers

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18
Q

what’s in stratum granulosum

A

more lamellar bodies and keratinohyaline granules

dehydrate the cells

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19
Q

what happens at the stratum granulosum

A

cells begin to die

due to dehydration and not vascularised

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20
Q

what happens when the cells die

A

lamellar Bodies are released, keratinohyaline granules fuse with monofilaments and form cross linked keratin

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21
Q

keratin

A

tight water proof layer

UV protection and pH stabilisation

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22
Q

stratum lucidum

A

only in thick skin
dead cell layer
several flattened cells thick and rich in eleidin

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23
Q

eleidin

A

a lipid rich protein, gives the layer a lucid appearance

24
Q

stratum corneum

A

thick superficial layer, thicker in thick skin

25
Q

thick vs thin skin

A
corneum is thicker in thick skin 
only thick has stratum lucidum 
thick has no hair follicles 
thick has no sebaceous glands 
thick has pacinian (lamellar) corpuscles 
both have sweat glands
26
Q

papillary dermis

A
  • loose irregular CT
27
Q

papillary skin

A

loose, irregular connective tissue

- loose so your skin can move around easily

28
Q

meissner’s corpuscle

A

in dermis, modified nerve ending
mechanoreceptor
highest density thick skin like finger tips

29
Q

reticular skin

A

dense irregular connective tissue
denser deposits of collagen and elastin fibres
thicker than papillary dermis

30
Q

reticular skin houses

A

glands and roots of hair follicles from the epidermis

31
Q

kraissl lines

A

lines of tension

incisions parallel to these lines heal better

32
Q

subcutaneous tissue

A

subcutis/hypodermis
from LP-m
coiled secretory components from sweat glands
nerves, vessels and capillaries in transit
houses pacinian corpuscles

33
Q

pacinian corpuscles

A

large concentric rings of fibroblast cells separated by gelatinous fluid surrounding a nerve ending
deep in the subcutis of thick skin only

34
Q

pacinian corpuscles detect

A

vibration

allows for sensation of textures

35
Q

melanocytes

A

sensitive to UV exposure

melanosomes are released

36
Q

melanosomes

A

absorbed by neighbouring cells
blocks UV
prevents DNA damage
increases risk of vid D deficiency

37
Q

melanocyte density

A

equal across all humans

38
Q

types of melanin

A

eumelanin - brown and black

pheomelanin - yellow-red

39
Q

3 manners of secretion of glands

A

merocrine
apocrine
holocrine

40
Q

merocrine

A

exocrine gland that uses exocytosis

41
Q

apocrine

A

cell surface breaks off and moves away

42
Q

holocrine

A

whole cell is broken up in components

43
Q

2 types of sweat glands

A

merocrine and apocrine

44
Q

merocrine sweat glands

A

excrete sweat onto skin surface
simple cuboidal/columnar with stratified cuboidal duct
ductal cells capable to reabsorb electrolytes

45
Q

apocrine sweat glands

A
excrete in terminal hair follicles 
simple cuboidal/columnar 
milky because has a bit of fat in it 
larger lumens
not thermoregulatory 
only found in terminal hair except for scalp
46
Q

holocrine glands example

A
sebaceous glands 
- excrete sebum (oily lipids) into hair follicles 
acing appearance (grapes)
47
Q

how sebaceous glands release sebum

A

cells closets to the duct explode, releasing sebum around the hair follicle

48
Q

vellus hair

A

wool/fleece

49
Q

terminal hair

A

on scalp

thicker

50
Q

hair shaft anchored at

A

root which has a bulb

51
Q

bulb

A

made up of epidermal stem cells

52
Q

bulb cell blood supply

A

from a papilla

53
Q

hair change during puberty

A

androgens convert vellus into terminal hair due to changes in blood supply

54
Q

hair as a sensory structure

A

nerve fibres surround hair and papilla

55
Q

erector pilli muscles

A

smooth muscle has autonomic control

sympathetic activation - contraction causes hair to stand on end