lymphatics

Question 1

location of the spleen

Answer 1

left hypochondrium

rib 10-11

Question 2

spleen develops from

Answer 2

intreperitoneal organ of the foregut

• not derived from gut tube
• developed from LP-M

Question 3

spleen held to stomach by

Answer 3

mesentery - gastrosplenic ligament

Question 4

size of spleen

Answer 4

variable

Question 5

spleen held to posterior body wall by

Answer 5

mesentery - splenorenal ligament

Question 6

blood supply to the spleen

Answer 6

arterial - celiac artery (splenic artery part)

venous - splenic vein (drains to portal view because it is unpaired)

Question 7

embryonic function of the spleen

Answer 7

ethrypoietic organ

becomes filter/immune after

Question 8

spleen functions post birth

Answer 8

mainly lymphoid organ
filters RBC
antigen presentation and immune response

Question 9

histology of the spleen

Answer 9

fibrous thin capsule
thin and wrapped in peritoneum
- dense irregular CT that send trabecular into the organ

Question 10

trabecular connected by

Answer 10

reticular fibres

Question 11

significance of capsule and trabecular

Answer 11

prone to rupture

Question 12

white pulp of the spleen

Answer 12

20% of splenic volume

splenic arterial branches between the trabeculae

Question 13

end branches have

Answer 13

peri arteriolar lymphoid sheaths

lots f T lymphocytes in the tunica externally (outside of the cells)

Question 14

lymphoid nodules

Answer 14

germinal centres

dense zone of aggregating and proliferting T lymphocytes

Question 15

central artery

Answer 15

in germinal centre

not central

Question 16

marginal zone

Answer 16

small arterioles and capillaries branch out into marginal zone
area where the blood vessels are moving more toward the red pulp

Question 17

efferent lymphatics

Answer 17

connect to white pulp

no afferent lymphatics

Question 18

red pulp

Answer 18

filtration and red blood cell modulation

75% of splenic volume

Question 19

filtration component of spleen

Answer 19

red pulp

mesh of venous sinusoids separated by the reticular spaces

Question 20

reticular spaces

Answer 20

lots of macrophages

Question 21

inter sinusoidal regions

Answer 21

open regions
arteriole and venous are not directly connected so blood must flow in open space
fibroblasts limit blood passage

Question 22

discontinuous endothelium

Answer 22

rod epithelial cells (stave cells)
connect in place but not everywhere
no proper basal laminar
non playable red blood cells are phagocytksed

Question 23

flow in the spleen

Answer 23

sinusoids, venules, trabecular vein, splenic vein

Question 24

lymph nodes function

Answer 24

filter lymph and survay for pathogens

Question 25

lymph node structure

Answer 25

thin fibrous captule with trabecular that extend deeper toward the phylum

Question 26

afferent lymphatics

Answer 26

only lymph nodes have this | input from other lymphatic vessels

Question 27

cortex of the lymph node

Answer 27

lymphoid nodules and germinal centres (have lots of B cells)

Question 28

lymph drains from afferent lymphatics into

Answer 28

into sub capsular sinuses

Question 29

lymph node cortex held together by

Answer 29

mesh of reticular fibres

Question 30

paracortex

Answer 30

contains T cells more

Question 31

high endothelial vessels

Answer 31

allow B and T cells to leave the blood vessels

Question 32

medulla of the lymph node

Answer 32

mesh of cords and sinuses

Question 33

cords

Answer 33

contain lymphocytes, macrophages and plasma cells | plasma cells secrete immunoglobulin (antibodies) into sinuses

Question 34

sinuses

Answer 34

lymph collection points for trabecular sinuses

Question 35

lymph vessels

Answer 35

similar to blood vessels | lack basal laminar to tend to collapse

Question 36

lymph vessels most abundant in

Answer 36

dermis of the skin, membrane CT and hepatic CT | important role in metastasis

Question 37

lymphatic vessels absorb and carry

Answer 37

interstitial fluid adds this to blood can include larger particles that cannot enter the sinus

Question 38

large particles that can't enter the blood system

Answer 38

lipids, foreign bodies, cell debris , lymphocytes, and eosinophilic proteins

Question 39

lymph nodes develop in

Answer 39

mesenchyme

Question 40

the thoracic duct starts at

Answer 40

the cisterna chyli

Question 41

cisterna chyli

Answer 41

collects lipids and fats from food | appears white due to lipid content

Question 42

common locations of lymph nodes

Answer 42

cervical, iliac, mesenteric, pulmonary etc