lymphatics Flashcards

1
Q

location of the spleen

A

left hypochondrium

rib 10-11

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2
Q

spleen develops from

A

intreperitoneal organ of the foregut

  • not derived from gut tube
  • developed from LP-M
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3
Q

spleen held to stomach by

A

mesentery - gastrosplenic ligament

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4
Q

size of spleen

A

variable

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5
Q

spleen held to posterior body wall by

A

mesentery - splenorenal ligament

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6
Q

blood supply to the spleen

A

arterial - celiac artery (splenic artery part)

venous - splenic vein (drains to portal view because it is unpaired)

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7
Q

embryonic function of the spleen

A

ethrypoietic organ

becomes filter/immune after

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8
Q

spleen functions post birth

A

mainly lymphoid organ
filters RBC
antigen presentation and immune response

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9
Q

histology of the spleen

A

fibrous thin capsule
thin and wrapped in peritoneum
- dense irregular CT that send trabecular into the organ

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10
Q

trabecular connected by

A

reticular fibres

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11
Q

significance of capsule and trabecular

A

prone to rupture

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12
Q

white pulp of the spleen

A

20% of splenic volume

splenic arterial branches between the trabeculae

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13
Q

end branches have

A

peri arteriolar lymphoid sheaths

lots f T lymphocytes in the tunica externally (outside of the cells)

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14
Q

lymphoid nodules

A

germinal centres

dense zone of aggregating and proliferting T lymphocytes

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15
Q

central artery

A

in germinal centre

not central

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16
Q

marginal zone

A

small arterioles and capillaries branch out into marginal zone
area where the blood vessels are moving more toward the red pulp

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17
Q

efferent lymphatics

A

connect to white pulp

no afferent lymphatics

18
Q

red pulp

A

filtration and red blood cell modulation

75% of splenic volume

19
Q

filtration component of spleen

A

red pulp

mesh of venous sinusoids separated by the reticular spaces

20
Q

reticular spaces

A

lots of macrophages

21
Q

inter sinusoidal regions

A

open regions
arteriole and venous are not directly connected so blood must flow in open space
fibroblasts limit blood passage

22
Q

discontinuous endothelium

A

rod epithelial cells (stave cells)
connect in place but not everywhere
no proper basal laminar
non playable red blood cells are phagocytksed

23
Q

flow in the spleen

A

sinusoids, venules, trabecular vein, splenic vein

24
Q

lymph nodes function

A

filter lymph and survay for pathogens

25
Q

lymph node structure

A

thin fibrous captule with trabecular that extend deeper toward the phylum

26
Q

afferent lymphatics

A

only lymph nodes have this

input from other lymphatic vessels

27
Q

cortex of the lymph node

A

lymphoid nodules and germinal centres (have lots of B cells)

28
Q

lymph drains from afferent lymphatics into

A

into sub capsular sinuses

29
Q

lymph node cortex held together by

A

mesh of reticular fibres

30
Q

paracortex

A

contains T cells more

31
Q

high endothelial vessels

A

allow B and T cells to leave the blood vessels

32
Q

medulla of the lymph node

A

mesh of cords and sinuses

33
Q

cords

A

contain lymphocytes, macrophages and plasma cells

plasma cells secrete immunoglobulin (antibodies) into sinuses

34
Q

sinuses

A

lymph collection points for trabecular sinuses

35
Q

lymph vessels

A

similar to blood vessels

lack basal laminar to tend to collapse

36
Q

lymph vessels most abundant in

A

dermis of the skin, membrane CT and hepatic CT

important role in metastasis

37
Q

lymphatic vessels absorb and carry

A

interstitial fluid
adds this to blood
can include larger particles that cannot enter the sinus

38
Q

large particles that can’t enter the blood system

A

lipids, foreign bodies, cell debris , lymphocytes, and eosinophilic proteins

39
Q

lymph nodes develop in

A

mesenchyme

40
Q

the thoracic duct starts at

A

the cisterna chyli

41
Q

cisterna chyli

A

collects lipids and fats from food

appears white due to lipid content

42
Q

common locations of lymph nodes

A

cervical, iliac, mesenteric, pulmonary etc