Sketchy Path: Crohn's and UC Flashcards
Ulcerative Colitis is defined as?
Recurring episodes of inflammation of the colonic mucosa
Ulcerative colitis affects only what areas?
Rectum and Colon
The inflammation of UC is said to continuous or patchy?
Continuous
what do you see on contrast enema of the colon during UC?
Lead pipe appearance since colon loses its haustra
What is elevated in UC?
p-ANCA
may also be in crohn’s but more assc with UC
What do you see on histology for UC?
Abscesses within colonic crypts
What is seen on endoscopy of the colon in UC?
Large broad base shallow ulcers with islands of normal tissue inside that look like polyps (also called pseudopolyps)
What is the pathophys behind toxic megacolon in UC?
Inflammation extends to the colonic smooth muscle leading to paralysis of the muscle and severe colonic dilation
Which IBD is assc with a higher risk of colorectal cancer?
UC
UC is assc with what other GI autoimmune disorder?
Primary sclerosing colangitis (PCS) which is autoimmune destruction of the intra and extrahepatic bile ducts
The lesions in Crohn’s disease are said to be what kind of lesions? What appearance does it give the GI tract?
Skip Lesions
Cobblestone
What antibody is present in Crohn’s disease?
Anti-Sacch antibodies (ASCA)
Which IBD are you likely to find hematochezia?
UC
can be seen in Crohn’s but less likely
What causes the malabsorption of fats in Crohn’s?
Bile acids are reabsorbed at the terminal ileum. This is where Crohn’s is most likely to be leading to poor reabsorption of bile acids
Which IBD is known for causing noncaseating granulomas?
Crohn’s
