Sketchy Path: Acute and Chronic Pancreatitis

Question 1

Pancreatitis always involves the activation of what enzyme?

Answer 1

Trypsin

Question 2

Which enzyme is associated with fat necrosis?

Answer 2

Lypase

Question 3

What causes the calcium precipitates in pancreatitis?

Answer 3

Fat binds to free calcium and this is visible on histology

Question 4

What is the most common cause of acute pancreatitis?

Answer 4

Gallstones

Question 5

Which familial hyperlipidemias are assc with pancreatitis?

Answer 5

Type 1
Type 4
type 5
Due to high TGs

Question 6

What iatrogenic procedure can cause pancreatitis?

Answer 6

ERCP

Question 7

What is the history for those with pancreatitis?

Answer 7

Sharp epigastric pain that radiates to the back

Question 8

What serum markers are used for pancreatitis?

Answer 8

Amylase and Lipase

Lipase more specific

Question 9

What electrolyte abnormality is seen in severe acute pancreatitis?

Answer 9

Hypocalcemia

Question 10

How does pancreatitis cause hypovolemia?

Answer 10

Fluid accumulates around the pancreas leading to third spacing

Question 11

Alcoholic pancreatitis will have what RBC pathology?

Answer 11

Macrocytes (large RBC)

Question 12

What is a pseudocyst in reference to pancreatitis?

Answer 12

Fat necrosis surrounded by a wall of granulation tissue

Question 13

What causes ARDS in pancreatitis?

Answer 13

Pancreas releases phospholipids as i starts to breakdown and this travels to the lungs and breaks down pulmonary surfactant

Question 14

Pancreatitis can cause thrombosis in what vein?

Answer 14

Splenic Vein

Question 15

Splenic vein thrombosis can lead to what?

Answer 15

Esophageal Varices from back up of the splenic vein