Sketchy Path: Carcinoid Tumor and SB neoplasms

Question 1

Carcinoid tumors are derived from what tissue?

Answer 1

Neuroendocrine

transformer with wires

Question 2

What is the most common tumor of the appendix?

Answer 2

Carcinoid tumor

Question 3

What is the most common type of primary lung cancer in children?

Answer 3

Bronchial Carcinoid Tumor

Kid in the sewage with the neuroendocrine goo on his chest coughing

Question 4

What do carcinoid tumors look like on Histo?

Answer 4

Islands of small round purple cells surrounded by pink connective tissue- can see dense granules in cytoplasm
(Lizard is painted pink and purple)

Question 5

Why don’t primary carcinoid tumors in the GI tract show symptoms?

Answer 5

Slow growing and the secretions are usually broken down by the liver (1st pass affect)
(Lizard eating histamine bee and serotonin smiley face pizza)

Question 6

What are the two most common substances secreted by carcinoid tumors?

Answer 6

Serotonin
Histamine
(histamine bee and serotonin pizza box)

Question 7

What is the most common symptom of carcinoid syndrome?

Answer 7

Episodic flushing of the face, neck, and chest

Liver lizard with red face and head

Question 8

Prolonged carcinoid syndrome can cause what to occur on the nose and cheeks?

Answer 8

Vascular Telangiectasias
(from vasodilation)
(Red face mask flowing in wind)

Question 9

Chronic secrotory diarrhea caused by carcinoid tumor is from what hormone being secreted?

Answer 9

Serotonin

Question 10

Carcinoid syndrome can cause what lung symptom?

Answer 10

Episodic bronchospasm and wheezing

lizard with the party blower

Question 11

Why is it important to distinguish Carcinoid bronchospasm from asthma induced bronchospasm

Answer 11

Asthma induced treatment is a Beta2 agonist but if you give that to carcinoid you are going to enhance vasodialtion and make it worse

Question 12

Serotonin mediated carcinoid syndromes can cause what to the heart?

Answer 12

Plaque vegetation on the Right sided valves- may lead to stenosis
(Heart shaped tube with slimy valves on right)

Question 13

Why do carcinoid tumors only affect the right side of the heart?

Answer 13

the lung metabolizes serotonin and therefore the left side is never exposed
(Lizard in the left side of heart tube eating pizza and bees)

Question 14

How are carcinoid tumors diagnosed?

Answer 14

5-HIAA in urine

Lizard kicking saying “HI-AA” near waterfall of urine

Question 15

Carcinoid tumors express a large amount of what receptors? How is this used for treatment?

Answer 15

Samotostatin
octerotide (Somatostatin analog) can treat
(Stop sign in the liver tube)

Question 16

How do adenocarcinomas of the SB start?

Answer 16

As an adenomatous polyp

Question 17

What two syndromes can increase your risk of developing SB adenocarcinoma?

Answer 17

FAP
(minions of mushrooms)

Lynch Syndrome
(Inch worm)

Question 18

What syndrome causes harmartomas throughout the gut particularly the small bowel?

Answer 18

Peutz-Jagher Syndrome

PJ the hammer wielding lizard

Question 19

What is a distiguishing feature of Peurz-Jegher syndrome?

Answer 19

Hyperpigmentations of the lips, palms, and genitalia

PJ the lizard with purple lips and hands

Question 20

Which IBD increases the risk of SB cancer?

Answer 20

Crohn’s Disease (UC is colorectal)

Cobblestoning of the terminal ileum pipe