SJS/TEN

Question 0

DRESS in AN HAT

Answer 0

• dress reaction: drug reaction with eosinophilia and systemic symptoms
• A: Abx (metro, sulfas), N: NSAIDs (meloxicam), H: HIV drugs (abacavir), A: allopurinol, T: tetracyclines

Question 1

PMS BiTches are NSFw and need to be fixed

Answer 1

• p: phenothalien, m: metronidazole, s: sulfas, b: barbiturates, t: tetracyclines, n: NSAIDs, s: salycilates, f: yellow food coloring
• fixed drug rxn
• typically single bulluos lesion

Question 2

Drug reactions assoc with. EBV/HIV

Answer 2

EBV: aminopenicillins
HIV: sulfa drugs (Sulfa Sex)

Question 3

Han Chinese susceptibility

Answer 3

HLA B1501: SJS/TEN in response to anticonvulsants (carbamazepine specifically)

Question 4

SATAN will give you SJS

Answer 4

• S: sulfa
• A: allopurinol
• T: tetracycline
• A: anticonvulsants
• N: NSAIDs

Question 5

HLA B1501/B1502

Answer 5

• 1501: SJS susceptibility with Han Chinese and anticonvulsants
• 1502: SJS susceptibility with white Europeans and allopurinol
  ~ 1301: in Europeans too

Question 6

HLA B5701

Answer 6

Abacavir SJS susceptibility

Question 7

Mediators of SJS/TEN (4)

Answer 7

• granulysin, granzyme B, perforin
• soluble fas ligand liberated by mellatoproteases
• granulysin associated with significant apos of keratinocytes

Question 8

Prohapten vs. pharmacological

Answer 8

• pro hapten response: drugs digested to substrates which triggers covalent formation of immune molecule
• pharmacological response: non-covalent binding of drugs at MHC I triggering apoptotic response

Question 9

Prognosis/diagnosis potential

Answer 9

High serum granulysin and high mobility protein B1

Question 10

Admission to burn unit in relation to toxic epidermolytic necrolysis

Answer 10

~ 50% lower with delay

Question 11

Nikolsky sign

Answer 11

Seperation of dermis from basal layer upon lateral pressure

Question 12

Asboe-Hansen sign

Answer 12

• lateral expansion of bulla upon pressure