Bone/Muscle Phys Basics Flashcards
0
Q
Collagen formation process
A
- Preprocollagen synthesis
- Hydroxylation of lysines and prolines
- Glycosylation of hydroxylysine and hydroxyproline
- Alpha chains assembled into procollagen (secretory product)
- Procollagen peptide sequences cleaved -> tropocollagen
- tropocollagen Assembled into collagen fibrils
1
Q
Collagen type essentials
A
- Type I: fibrocartilage, bone, dentin
- Type II: cartilage
- Type III: loose/dense CT
- Type IV: basal Laminae
- Type VII: high stress areas (palms, soles)
- Type XI: FACIT linkage collagen
- Type X: epiphyseal marker (Zone of hypertrophy and mineralization)
2
Q
Sarcaromere signal transduction
A
- A/P Transmitted down the sarcolemma -> t tubule
- ryanodine receptor senses voltage delta and opens calcium channels -> SR efflux
- Ca is quickly reuptaken by Ca pumps and sequestered by calcequestrin
3
Q
Troponin/myosin/tropomyosin
A
- Tropomyosin hides actin binding site from myosin
- troponin T binds tropomyosin
- troponin I binds troponin c and actin
- troponin C binds calcium and pulls on troponin T pulling on tropomyosin exposing binding site
4
Q
Osteopontin
A
- Promote cell infusion to extra cellular matrix including osteoclasts to bone
5
Q
Chondronectin
A
- Chondrocyte binding, collagen type II, binding proteoglycan binding
6
Q
1B afferent
A
- Fibers carrying GTO reflex information
7
Q
Zone of proliferation
A
- Contains chondrocytes forming isogenous groups in rows
- hGF -> IGF -> mitosis
8
Q
Zone of hypertrophy
A
- Secretes ALPase -> Begins breaking down the vertical columns between them
9
Q
Type A synoviocytes
A
- Macrophages well-developed Golgi apparatus and only a small amount of rough ER
- Clears debris from joint space
10
Q
Type B synoviocytes
A
- Create synovial fluid as ultrafiltrate from blood
- Ultrafiltrate contains hyluronic acid and lubricin
