Bone/Tumors

Question 0

Tumor composed of woven and lamellar bone frequently deposited in cortical pattern with haversian like systems

Answer 0

Osteoma: typically benign and subclinical

Question 1

Two most common benign tumors

Answer 1

• Osteochondroma

- fiberous cortical defect

Question 2

A tumor producing nocturnal pain that is relieved by aspirin in a young male that is less than 2 cm

Answer 2

Osteoid osteomas and osteoblastomas

Question 3

Bulky tumor with the gritty gray white mass content areas of hemorrhage and cystic degeneration

• This tumor presents with a bimodal distribution: younger than 20 years and the elderly
• knees>hips>maxilla/mandible

Answer 3

• osteosarcoma

- Typically arises from the defect in RB and p53 and occasionally INK4a for a which encodes for p16

Question 4

Prominent bone extending into soft tissues with radiographic codman triangle

Answer 4

• osteosarcoma

Question 5

Benign cartilage capped Bony extension

Answer 5

• osteochondroma
• loss of EXT1/EXT2
• typically in long bones or pelvis (rarely in distal extremities)

Question 6

A small glossy gray blue translucent tumor associated with both Ollier and maffucci syndrome

Answer 6

Enchondromas

- 20s and 40s

Question 7

A rare benign tumor composed of sheets of polyhedral chondroblasts set in scant amounts if hyaline matrix

• typically painful
• assoc with effusion and restriction of movement

Answer 7

• chondroblastoma

Question 8

Chondromyxoid vs. sarcoma

Answer 8

• chondromyxoid involves lobules of hyaline matrix

- chondrosarcoma also contains malignant, non-uniform and dysplastic cells

Question 9

A dysplastic tumor arising in the axial skeleton with a nodular growth pattern of endosteal CSalloping

Answer 9

Chondrosarcoma

Question 10

Elongated sharply demarcated radiolucent surrounded by a rim of sclerosis: lobulated
- Yellow brown cellular lesions containing fibroblasts macrophages arranged in storiform pattern

Answer 10

Fibrous cortical defect

Question 11

Tumors associated with polyostotic disease café au lait skin pigmentation’s and precocious puberty
- GNAS mutation

Answer 11

Fiberous dysplasia

• monostotic: lesion involving only one bone - 70%
• polyostotic without endocrine: often involves craniofacial lesions
• polyostotic with endocrine: Café au lait spots sexual Precocity hyperthyroidism
• lesions have storiform, grossly ground glass appearance

Question 12

Large hemorrhagic tan/white tumors destroying underlying tissue with a herringbone storiform patten

Answer 12

• Fibrosarcoma

Question 13

A small tan white saw tumor containing areas of hemorrhage and necrosis composed of uniform sheets of small round cells.
- Homer-wright rosettes

Answer 13

Eweing/PNET tumors (neuroectodermal)

Question 14

Large red-brown tumors that undergo cystic degeneration. There composed of uniform oval mononuclear cells (type and epidem)

Answer 14

• giant cell tumor (osteoclastoma)

- 20-40s