Integument Flashcards
0
Q
Condition effecting s. spinosum
A
- epidermiolytic hyperkeratatosis
1
Q
Condition affecting S. basale
A
- epidermiolytic bullosa simplex
2
Q
Conditions affecting S. granulosum
A
Epidermiolytic palmaplantar keratoderma
3
Q
Condition resulting Desmosomes defects
A
Striate plantopalmar keratoma
4
Q
Conditions from cornified cell envelope defect
A
- transglutaminase (TGA- 1)
- Vohwinkel syndrome (loricrin)
- congenital ichthyosiform erythroderma (TGA-1)
5
Q
Abnormal lipid metabolism affecting (CCE)
A
Sjogrens-Larsson syndrome
6
Q
Desmoglein 1 and 3 defects
A
- pemphigus foliaceous D1
- pemphigus vulgaris D3
7
Q
Exfoliation
A
- regulated proteolytic process
- ## killikrein related serine peptidases (pH dependent)
8
Q
Excess MTIF
A
- causes over production (MTIF is sequestered in nucleus until activated by a-MSH + MCR1 -> cAMP -> CREB -> MTIF txn
- occurs in melanoma
9
Q
Melanosome transport
A
- kinesin transports melanosome along Mtube to bind melanophilin, which complexes with myosin Va which walks up F actin to exocytosis melanosome
10
Q
transglutaminase (TGA- 1)
A
- cornified cell envelope defect
11
Q
- Vohwinkel syndrome (loricrin)
A
- cornified cell envelope defect
12
Q
- congenital ichthyosiform erythroderma (TGA-1)
A
cornified cell envelope defect
13
Q
Condition involving BPAG -> hemidesmosomes
A
Bulluos pemphigus
14
Q
Keratins 5 + 14
A
Epidermolytic bullosa simplex
15
Q
Keratins 1 + 10
A
Epidermolytic hyperkeratosis
16
Q
Keratin 9
A
Epidermolytic plantopalmar keratoderma
17
Q
Desmoplakin (Cadherin) disorder
A
- striate plantoplamar keratoderma
18
Q
Defects in TGA-1 and loricrin
A
- Vohwinkel syndrome (loricrin), congenital icthyosiform erythroderma (TGA-1)
