Drugs Flashcards
0
Q
Azelaic acid
A
- MOA: direct inhibition of P. Acnes, tyrosinase inhibitor (trt hyper pigmentation)
- use: hyper pigmentation
1
Q
Topical retinoids
A
- Tretinoin, Adapalene, Tazarotine (cat X)
- MOA: Comedolysis, antiinflammatory, normalization of epi
- really common in acne
2
Q
Topical dapsone
A
- MOA: anti-inflammatory, inhibits PMNs, anti-microbial
- if used with benzoyl peroxide -> yellow pigmentation (separate use by 20-30 mins)
3
Q
Erythromycin
A
- MOA: macrolide (50s subunit inhibition)
- Use: reduce lesions in P. Acnes (second line after tetracycline)
- resistance, GI upset: take with lipid
4
Q
Clindamycin
A
- MOA: 50s subunit binder: combo with benzoyl peroxide
- Use: decrease # of lesions
- pseudomembranous colitis risk
5
Q
Tetracycline
A
- MOA: 30s subunit binding
- Use: deep papules or nodules (tetracycline first line microbial)
6
Q
Minocycline
A
- doxy
- Sx: drug induced lupus (anti histone Ab)
- Sx: pseudo tumor cerebri
- Sx: blue/black pigment
7
Q
Triamicinalone
A
- MOA: phoslip 2a inhibition
- Use: acne emergencies (acne fulminans)
- use to prevent scarring
8
Q
Isoretinoin
A
- systemic (oral) retinoic acid derivative CAT X
- MOA: sebum suppression, anti inflammatory
- use: recalcitrant acne
- dryness (related to lack of oils)
9
Q
Psoralen + UVA
A
- MOA: increases skin sensitivity to light, slows growth of new skin
- use: generalized psoriasis
- Sx: skin cancer
10
Q
Acitretin
A
- MOA: binds nuclear txn factors, reduce hyperplasia
- Use: psoriasis
- Sx: lipid elevation
11
Q
Methotrexate
A
- MOA: DHFR inhibition
- Use: psoriasis
- Sx: hepatotoxicity, lung fibrosis
12
Q
Cyclosporine
A
- MOA: binds cyclophilin -> inhibits calcineurin -> inhibits IL2
- Use: psoriasis
- Sx: nephrotoxicity
13
Q
Azathiopine
A
- MOA: 6-MP analog -> inhibits de novo purine synthesis
- Use: psoriasis
- Sx: lots
14
Q
Etanerctept, inflixumab, adilimumab
A
- MOA: cytokine inhibition (TNFa inhibitor)
- Use: psoriasis
- Sx: infection (TB activation)
