Drugs Flashcards
Azelaic acid
- MOA: direct inhibition of P. Acnes, tyrosinase inhibitor (trt hyper pigmentation)
- use: hyper pigmentation
Topical retinoids
- Tretinoin, Adapalene, Tazarotine (cat X)
- MOA: Comedolysis, antiinflammatory, normalization of epi
- really common in acne
Topical dapsone
- MOA: anti-inflammatory, inhibits PMNs, anti-microbial
- if used with benzoyl peroxide -> yellow pigmentation (separate use by 20-30 mins)
Erythromycin
- MOA: macrolide (50s subunit inhibition)
- Use: reduce lesions in P. Acnes (second line after tetracycline)
- resistance, GI upset: take with lipid
Clindamycin
- MOA: 50s subunit binder: combo with benzoyl peroxide
- Use: decrease # of lesions
- pseudomembranous colitis risk
Tetracycline
- MOA: 30s subunit binding
- Use: deep papules or nodules (tetracycline first line microbial)
Minocycline
- doxy
- Sx: drug induced lupus (anti histone Ab)
- Sx: pseudo tumor cerebri
- Sx: blue/black pigment
Triamicinalone
- MOA: phoslip 2a inhibition
- Use: acne emergencies (acne fulminans)
- use to prevent scarring
Isoretinoin
- systemic (oral) retinoic acid derivative CAT X
- MOA: sebum suppression, anti inflammatory
- use: recalcitrant acne
- dryness (related to lack of oils)
Psoralen + UVA
- MOA: increases skin sensitivity to light, slows growth of new skin
- use: generalized psoriasis
- Sx: skin cancer
Acitretin
- MOA: binds nuclear txn factors, reduce hyperplasia
- Use: psoriasis
- Sx: lipid elevation
Methotrexate
- MOA: DHFR inhibition
- Use: psoriasis
- Sx: hepatotoxicity, lung fibrosis
Cyclosporine
- MOA: binds cyclophilin -> inhibits calcineurin -> inhibits IL2
- Use: psoriasis
- Sx: nephrotoxicity
Azathiopine
- MOA: 6-MP analog -> inhibits de novo purine synthesis
- Use: psoriasis
- Sx: lots
Etanerctept, inflixumab, adilimumab
- MOA: cytokine inhibition (TNFa inhibitor)
- Use: psoriasis
- Sx: infection (TB activation)
Tacrolimus, pimcrolimus
- MOA: calcineurin inhibition -> IL2 down reg.
- Use: in atopic dermatitis in kids < 2, second line if roids don’t work
- risk if neoplasm and tons of others
Mupirocin/retapamulin and cephlexin
- MOA: various
- Use: super infected dermatitis
Acyclovir
- MOA: antiviral
- use: suspected eczema herpetica
Scopolamine
- MOA: percutaneous muscarinic agonist
- use: motion sickness
Nitroglycerin
- MOA: NO production -> vasodilation
- Use: angina
- tolerance can develop
Clonadine
- MOA: central a-adrenergic agonist
- Use: anti-hypertensive
Hormones: combipatch, estradiol, ortho Vera
- hormone replacement, contraceptive (ortho Vera)
Fentanyl
- opioid analgesic
- chronic pain management
Lidocaine
- topical analgesic/anesthetic
- herpes zoster
Testosterone
- applied to sacrotum or lower back
- hormone replacement
UVA/UVB therapy
- A penetrates more deeply, Atopic dermatitis
- B is more narrow band, psoriasis
Griseofulvin
- treatment of choice for tinea capitis
- MOA: microtubule inhibition
Terbenifine, itrocazole
- use: tinea
Primetherim ivermectin
- scabies treatment
- use of ivermectin for immunocomp
Keratin pearls
- Invasive squama cell carcinoma
Vismodegib
- treatment of BCC, in people not candidates for surgery
- MOA: involves inhibition of sonic hedgehog
- cat X
Stage IV melanoma trt
- palliative therapy primary
- lpilimumab, vemurafenib (CTLA MoAb, and other)
