Sjogren Syndrome

Question 1

Chronic, slowly progressive autoimmune disease

Answer 1

Sjogrens syndrome

Question 2

Oral symptoms of sjogren syndrome

Answer 2

Xerostomia

Parotid gland enlargement

Question 3

Ocular involvement

Answer 3

Decreased tearing
Keratoconjunctivitis sicca
Xerophthalmia

Question 4

Extraglandular manifestation

Answer 4

Arthralgia
Arthritis
Lymphoma

Question 5

Xerostomia, keratoconjunctivitis sicca only

Answer 5

Sicca syndrome

Question 6

Lack of antibodies to Ro/SS-A & La/SS-B
Lymphoid infiltrates of salivary gland by CD8+ Lymphocytes
HLA-DR5
+ HIV

Answer 6

Sicca syndrome

Question 7

Production of tears test

Answer 7

Shirmir’s test

Rose Bengal score

Question 8

Diagnostic for sjogrens

Answer 8

+ Ro/SS-A & La/SS-B

Question 9

+ Cardiolipin

Answer 9

SLE & APAS

Question 10

Sjogren syndrome

Answer 10

Carbonic anhydrase II

Question 11

Centromere-associated proteins

Answer 11

Systemic sclerosis

Question 12

If have interstitial nephritis? Give

Answer 12

Corticosteroid

Question 13

Triad of sjogrens

Answer 13

Xerostomia
Keratoconjunctivitis sicca
RA / SLE / Lymphoma

Question 14

For primary biliary cholangitis

Answer 14

AMA ( anti-mitochondrial antibody)

Question 15

Most common extraglandular involvement

Answer 15

Glandular MALT lymphoma

Question 16

Treatment for sjogrens

Answer 16

Initially with glucocorticoids

Maintenance with AZA or mycophenolate mofetil

Question 17

Used for lubrication of eyes

Answer 17

Water or artificial tears

Question 18

For arthritis

Answer 18

Hydroxychloroquine

Methotrexate

Question 19

Tx for reynaudks phenomena

Answer 19

Nifedipine

Question 20

Tx for renal tubular acidosis

Answer 20

Bicarbonate

Question 21

Tx for lymphoma

Answer 21

R - CHOP or CHOP

Rifampin
Cyclophosphamide
Doxurubicin
Vincristine
Prednisone

Question 22

HLA related to sjogren syndrome?

Answer 22

HLA-DR3

DRw52

Question 23

Granulomas in salivary gland

Answer 23

Sarcoidosis