Hypertension Flashcards
Normal BP
< 120/<80 mmHg
Elevated BP
120-129/<80 mmHg
Stage 1
130-139/80-89 mmHg
Stage 2
> 140/>90 mmHg
What is most common cause of secondary HPN?
Primary renal disease
Pheochromocytoma
24h urinary fractionated metanephrines
Cushings syndrome test
Dexa suppresion test
Urinary metabolite in pheochromocytoma
VMA
Primary hyperparathyroidism test
Serum Ca
Cushing triad
Moon facies
Buffalo hump
Abdominal striae
High BP in upper ex, lower BP in lower ex
Coarctation of aorta
HPN, HYPOKALEMIA, NORMAL RENIN AND ALDOSTERONE
Congenital adrenal hyperplasia
High GH after closure of epiphyseal plates, in adults
Acromegaly
Prognathism, frontal bossing
Acromegaly
High GH before closure of epiphyseal plates, in children
Gigantism
DOC for ACROMEGALY
Octreotide
Initial diagnostic test for primary HPN
TSH
Optional tests
Echo, uric acid, urinary albumin to crea ratio
Early marker of renal injury, and risk factor for renal disease progression and CVD
Urinary albumin/ creatinine ratio
Random A/C ratio , > 300 mg/g
Macroalbuminuria
Random A/C ratio 30-300 mg/g
Microalbuminuria
Classic symptom of Peripheral arterial disease
Intermittent claudication
Diagnostic of PAD
Ankle brachial index <0.90
ABI
Ankle systolic pressure / brachial systolic pressure
Normal ABI
0.91- 1.29
Diminished pulse Associated with heavy smoking
Buerger’s disease
IGA nephropathy
Bergers disease
Non pharma highest SBP lowering effect in HPN
DASH diet ( -11 mmHg)
DASH diet
Dietary approaches to stop hypertension
DASH Sodium limit
1500 mg/day
Diabetes mellitus
> 130/80 threshold
Goal: <130/80
Secondary stroke prevention BP threshold
> 140/80
Thiazide diuretics WOF
Hyperuricemia, hyponatremia, hypokalemia
Risk for hyperkalemia, avoided in pregnancy, ARF in severe Bilateral RAS
ACEi/ARB
No no no
ACEi + ARB
ACEi in pregnant women
Renal Agenesis
Do not use in HFrEF (HF with reduced Ejection fraction) bec negative inotropic effect
CCB nondihydro/ dihydro
Increased brady and heart block
CCB nondihydro + Beta Blockers
Avoid mixing!
Preferred for symptomatic HF
Loop diuretics
Preferred for primary aldosteronism and resistant HPN
Spironolactone and eplerenone
Gynecomastia and impotence
Spironolactone
Beta blocker cause gynecomastia
Cimetidine
Anti fungal cause gynecomastia
Ketoconazole
Beta blocker noncardioselective
Avoided in Reactive airway disease
Propanolol
Preferred in HF with reduced Ejection fraction
Bisoprolol and metoprolol sipuccinate
Beta blockers with alpha and beta receptor activity
Carvedilol, labetalol
Also preferred in HFrEF
Carvedilol
Direct renin inhibitor, do not combine with ACEi or ARB BEC increased risk HyperKalemia
Alliskrein
Alpha 1 blockers, orthostatic hypotension
Terazosin, prazosin
Central alpha 2 agonist, last line
Clonidine, methyldopa
Hypertensive crisis
> 180/>120 with organ damage
Widening of mediastinum in xray sign
Aortic dissection/ rupture
Target organ damage in hypertensive emergency
Eyes, brain, heart, kidney
Flea bitten kidney, fibrinoid necrosis of arterioles - “onion skin”
Malignant hypertension
Cause of cyanide toxicity
Cyanide poisoning