Silveira - GWAS and polygenic score Flashcards
1
Q
What is one way to assess multilocus effects in genetic variant risk studies?
A
Assign scores to different polymorphic variants and sum a cumulative index
2
Q
What is a GWAS?
A
Genome Wide Associated Study -> tries to find associations between phenotypes and genetic variants (most often SNPs) by comparing genetic data from control and genetic data from clinical population
3
Q
How is a polygenic risk score calculated?
A
Sum of risk alleles count weighted by GWAS effect sizes (for each allele) -> calculated for a single individual
4
Q
A polygenic score can be grossly calculated from multiplying two matrices, which ones?
A
Matrix indicating alleles at risk and how many (1 or both) x matrix indicating effect size for each risk allele
5
Q
A
6
Q
A
