Silveira - Gene-by-environment interactions

Question 1

What is the heterogeneity issue in studying mental health? How does it relate to population vs. individual values?

Answer 1

Possible to find patterns at population level
However strong variance in individual scores

Question 2

How can the same SNP lead to different effects across different cell types (e.g., tissue-specific)

Answer 2

Interfering with TF, regulatory element, epigenetic process, etc.

Question 3

True or false: single genes have been found to fit the differential susceptibility model.

Answer 3

True e.g. DRD4

Question 4

How can the impact of ELA be modulated by gender?

Answer 4

Gender can change the perception of ELA = yields different effects according to interpretation

Question 5

What is a common blunder from gene-environment interactions?

Answer 5

Consider genetic background as stable (at least not true bc. of epigenetics)