Signaling Mechanism & Drug Action Flashcards
1
Q
Signaling mechanism
A
- physiological stimuli
- receptor
- second messenger
- effector
- responses
2
Q
Intracellular receptors (nuclear R)
A
3
Q
Receptor tyrosine kinase
A
ex. growth factors
4
Q
Receptor Tyrosine Kinases & JAK-STAT pathway
A
5
Q
Ligand-gated ion channel
A
6
Q
G-protein coupled receptor
A
7
Q
What are some examples of GPCRs?
A
8
Q
What is desensitization in GPRCs?
A
Long-term use of drugs renders them ineffective
9
Q
Down regulation of GPCRs
A
G protein is activaes, R becomes Phosphorylated and internalized. cannot be used anymore
10
Q
What are some secondary messengers?
A
cAMP, phosphoinositides, Ca2+
11
Q
Therapeutic strategy of Asthma
A
-relax airway SM by incrasing cAMP
