Absorption: Routes of Administration Flashcards
1
Q
Absorption rate is proportional to?
A
the blood flow at the site of administration
2
Q
Plaace in order of decreasing absorption rate (IV, IM, SubQ)
A
IV>IM>SubQ
3
Q
Which has a slow absroption rate? Oral or SubQ
A
SubQ (1x/3mo) are slower than oral contraceptive (1x/day) administration
4
Q
First pass effect
A
portion of drug administered is eliminated by gut wall, portal circulaiton, or liver before reaching systemic cicrulation
5
Q
What systems does first pass effect occur in?
A
- oral administration
- rectal administration (partially)
6
Q
What is bioavailability?
A
the fraction of administered dose which reaches the systemic circulation
7
Q
What equation is used to calculate bioavailability?
A
mass (total mass absorbed)= mass (total mass administered) * Bioabailability (route)
8
Q
A
