Distribution: Dist & Apparent Vol of Distribution

Question 1

Absorption deals with?

Answer 1

mass

Question 2

Distribution deals w/?

Answer 2

volume

Question 3

What is distribution?

Answer 3

The dispersion of a drug throughout your body

from: vascular space to: extravascular space( fat, muscle, nervous system)

Question 4

How does the concentration equation change when looking at distribution?

Answer 4

C(ideal)= total mass absorbed/ Volume (which the drug is distributed)

-the volume includes the plasma and extravascular space

Question 5

What does IV bolus: Concentration vs time graph with distribution (no met or excretion) look like?

Answer 5

Question 6

What is the Concentration of the drug in plasma with low Vd?

Answer 6

if drug stays in plasma then it will have a high concentration.

ex. plasma protein bound, H2O soluble, large MW

Question 7

What is the Concentration of the drug in plasma with high Vd?

Answer 7

if drug gets widely distributed then the concentration will be decreased

ex. lipophilic, binds to extravascular tissues, small MW

Question 8

What are some determinants of Vd?

Answer 8

1. properties of the drug: can the drug get through the vascular ensothelium and into extravascular space?
2. size of extravascular space: estimated from weight of people. obese will have larger vascular & extravas space.

Question 9

how do you calculate the Apparent volume of distribution?

Answer 9

Vd (L/kg) * weight (kg)

Question 10

Does Warfin have a high or low Vd?

Answer 10

high degree of plasma protein binging-stays mostly in blood. low Vd

Question 11

Does Gentamicin have a high or low Vd?

Answer 11

low Vd. large water soluble molecule- stays in extracellular water

Question 12

Does EtoH have a high or low Vd?

Answer 12

small water soluble molecule- it goes where water goes

Question 13

Does Chloroquine have a high or low Vd?

Answer 13

high Vd. highly lipophilic. very little stary in vascular compartments–>gets into fat and most tissues