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Pharmacology-1 > Autonomic Pharmacology > Flashcards

Autonomic Pharmacology Flashcards

1
Q

What type of movement is incolved in the Somatic Nervous system?

A

voluntary movement

-motor cortex(UMN)–>Spinal cord (LMN) ant. horn

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2
Q

What is the neurotransmitter in SMS and receptor?

A

ACH, Nicotinic Ach R

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3
Q

What are the two Acetylcholin Receptors?

A
  1. Nicotinic
  2. Muscarinic
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4
Q

What are the Nicotinic agonist? Type of R? Found?

A
  1. ach, nicotine
  2. Ligand-gated ion channel
  3. found in:

CNS, Neuromuscular jxn,

autonomic ganglia & Adrenal Medulla

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5
Q

What is the presynaptic nt releases? To what receptor?

A
  1. Ach
  2. Nicotinic
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6
Q

What are the muscarinic R agonist? type of R? Found in?

A
  1. ach, muscarin
  2. GPCR
  3. CNS, Autonomic effector organs (esp. PNS)
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7
Q

postsynaptic neurons of the PNS releases ACH onto what R? Target?

A
  1. Muscarinic
  2. Effector organs & sweat glands
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8
Q

What are the adregergic receptor subtypes? what type of R?

A

GPCRs

Alpha (1,2) * Beta (1,2)

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9
Q

What are the endogenous adrenergic R Agonist?

A
  1. Epinephrine
  2. Norepinephrin
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10
Q

Epinephrine is the agonist at what receptor sub-types?

A

alpha-1, alpha-2, beta-1, beta-2

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11
Q

What are the receptor sub-types for NE?

A

alpha-1, alpha-2, beta-1, **NOT **beta-2

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12
Q

What is the target of dopamine?

A

D receptors in smooth muscle of renal and splanchnic vasculature–>vasodilation

  • part of the SNS
  • synthesized by adenergic nerves, pleased from postsynpatic neuron
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13
Q

The postsynaptic neuron in the SNS released NE which binds to what receptors?

A

alpha and beta adregergic receptors.

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14
Q

What is the adrenal medulla like? What nt does it release?

A

like sympathethic ganglion, releases Epi & NorEpi

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15
Q

What does Hemicholinum target?

A

inhibits choline uptake

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16
Q

How is acetylcholine made?

A
  1. choline uptake
  2. choline acetylated by ChAT
  3. uptake into vesicles
  4. Ca++ influx causes vesicle to fuses with presynaptic membrane
  5. Signal terminated by AchE hydrolysis
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17
Q

What does vesamicol target?

A

inhibits uptake of Ach into vesicles

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18
Q

What does botulinum toxin target?

A

blocks vesicle fusion w/ presynaptice membrane

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19
Q

How is Epinephrine made?

A
  1. tyrosine uptake
  2. tyr–>DOPA
  3. . DOPA–>Dopamine
  4. DA uptake into vesicles
  5. DA–> NE
  6. Ca2+ influx causes vesicles to fuse and release NE
  7. Signal terminated by NE diffusion, metabolism, & reuptake
20
Q

What is the target of meyrosine?

A

inhibits Try–DOPA

21
Q

What does reserpine target?

A

Dopamine uptake into vesicles

22
Q

What is the target of guanethidine?

A

prevents fusion of vesicles.

23
Q

How does amphetamine affect NE?

A

impairs reuptake

24
Q

How does Cocaine affect NE?

A

Impairs reuptake

25
What is the mechanism of Tricyclic Antidepressants?
Impairs reuptake
26
How does the cholinergic signal terminate
Ach Hydrolysis
27
How does the adrenergic signal terminate?
1. reuptake into presynaptic terminal 2. diffusion 3. metabolism (MOA, COMT)
28
What is Pheocromocytoma?
adrenal medullary tumor: -too much NE, EPI produced
29
What is the clinical symptoms of Pheochromocytoma?
1. HTN, Tachy, diaphoresis (sweating) 2. headache, chest pain, abdominal pain, 3. skin flushing (and/or pallor)
30
How is pheochromocytoma diagnosed?
diagnosis confirmed by 24hr urine test -increased metanephrines, HMA, & VMA
31
Sympathetic
"fight or flight" thoracolumbar need to run away from tiger at night need to see, need oxygen/glucose at cells; no time to pee/poo or have baby
32
Parasympathetics
"rest and digest" craniosacral (CN 2,7,9, 10, Sacra N S2-S4) reading a book while sitting on the toilet in the sun
33
Differences btw SNS and PNS
34
Alpha 1 actions? what type of g protein class
\*\* Vascular SM contraction (raises BP)
35
Alpha 2 actions. Gprotein type?
36
Beta 1 actions. Receptor type? Does Epi/NE act here?
\*\*increases HR and contractility -increase renin release and lipolysis Gs
37
## Footnote Beta 2 actions. Receptor type? Does Epi/NE act here?
ONLY Epi acts on the R. \*\*relaxes SM bronchodilation
38
What does the alpha-2 presynaptic autoR do?
negative FB, thus make less NE
39
What do the alpha-2 presynaptic heteroR do?
1. angiotensin- enhances NE release 2. muscarinic- decreases NE release
40
Summary of G-protein linked 2nd messengers
41
## Footnote Autonomic and hormal control of cardio fxn
42
What is the effect of alpha adrenergic on the eye?
dilate pupil
43
## Footnote What is the effect of beta adrenergic on the eye?
produces aqueous humor
44
## Footnote What is the effect of muscarinic on the eye?
contricts pupil and accomodates near vision
45

Pharmacology-1 (15 decks)

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