Signal transduction (cell to cell signaling) Flashcards

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1
Q

signals tell cell to…

A
  • survive
  • divide
  • differentiate
  • die
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2
Q

steps of signal transduction

A
  • signaling molecule bind to receptor (receotion)
  • transduction (relay molecules)
  • response OR termination
  • ex: TF –> gene expression
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3
Q

important transcription factors

A
  • homeodomain-containing TF (Hox, Pax, Lim)
  • helix loop helix TF
  • zinc finger TF
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4
Q

What are homeodomain containg TFs

A
  • distinctive DNA binding sequence preferences
  • contribute to specificity in target genes and diversity in function among homeodomain proteins
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5
Q

example of homeodomain containing tf

A
  • hexapeptide: Hox
  • engrailed
  • Paired: pax
  • LIM
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6
Q

What are Hox TF

A
  • pattern the anterior posterior body axis playing crucial role in segment specific organogenesis
  • normal temporo-spatial limb and organ development
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7
Q

How are Hox TFs similar to combinatorial gene control

A
  • diff hox genes control expression in diff segments
  • order of genes in chromosome specifies order in time of their expression and where expressed spatially
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8
Q

Describe loss of function Hox TFs

A
  • if a segment is KOed, the expression will be taken over by another segment…
    ex: KO band of XIHbox1 expression… hindbrain will take over that area
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9
Q

Pax TFs

A
  • important for developmental steps… regional specification
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10
Q

LIM TFs

A
  • involved in tissue patterning and differentiation… specifically neural patterning (head development)
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11
Q

Helix-loop-helix transcription factors

A
  • basic helix-loop-helix: MyoD (muscle pattern .. master regulator TF)
  • forkhead: FOX
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12
Q

Zinc finger transcription factors

A
  • zinc finger: sox, WT1, Kruppel
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13
Q

sox

A
  • works together with other Tf’s
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14
Q

regulatory gene hierarchy

A
  • cascade of gene expression (genes that encode TFs)
  • gene products in each class control expression of genes in next class
  • results in:
  • stepwise organization of embryo… smaller and smaller regions until segmentation
  • same gene function at different period of development or in diff organs
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15
Q

Genes that guide development are..

A
  • conserved
  • earliest stages of human development occur under less rigid genetic control
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16
Q

mutation of pax genes leads to…

A
  • larger segments of regions
17
Q

mutation in pax gene

A
  • larger segmented regions
18
Q

genetic hierarchy

A
  • top to bottom
    maternal effect genes
    gap genes
    pair rule genes
    segment polarity genes
    homeotic genes
19
Q

one of the principal themes in contemporary cancer research is

A
  • role of mutant forms of developmentally important genes in converting normal cells to tumor
20
Q

signaling molecules and pathways

A
  • paracrine factors : diffusion of inducers from one cell to another
  • matrix: matrix of one cell induces change in another
  • contact : contact between inducing and responding cells
21
Q

paracrine factors

A
  • fibroblast growth factors (FGF)
  • related growth factors (EGF)
  • TGF-B superfamily
  • hedgehog
  • Wnt (wingless)
22
Q

antagonists of paracrine factors

A
  • noggin (BMP)
  • chordin (BMP)
23
Q

FGF and TGF-B pathways

A
  • know graph
24
Q

Growth factor to RTK

A
  • GF -> RTK -> Ras -> MAPK cascade
25
Q

Describe FGF complexity

A
  • same protein discovered in different contexts
  • biologically can interact in different ways to do different things, despite being the same protein
26
Q

TGF-B to TGF-B/Smad signaling pathway

A

see graph

27
Q

hedgehog signaling pathway

A
  • hedgehod inhibit patched
  • patched inhibit smoothened
  • smoothened activate Ci protein made activator (Gli)
  • activates transcription
28
Q

Wnt signaling pathway

A
  • see figure
  • Wnt activate frizzle
  • frizzle activate disheveled
  • DSh inhibits GSK3
  • GSK3 inhibit B-catenin
  • B-catenin activate transcription
29
Q

Direct cell contact

A
  • delta notch
  • cadherin (homophilic)
  • other cell-cell adhesion molecules
30
Q

delta-notch

A
  • direct contact cell signaling
  • communication
  • controls cell differentiation processes during embryo/adult life…
  • dysregulated in cancer
  • lunatic fringe
31
Q

Where do you see delta-notch signaling

A
  • gliogenesis
  • left-right asymmetry determination
  • somite function
32
Q

lunatic fringe

A
  • acts in golgi to modify notch and alter notch’s ability to bind to its ligand Delta
  • established anterior boundary of somites
33
Q

cell to cell adhesion molecules

A
  • see figures
34
Q

extracellular matrix signaling moelcules and pathways

A
  • integrin:
  • principal receptors used by animal cells to bind to extracellular matrix
  • heterodimers and
  • function as transmembrane linkers between the extracellular matrix and actin cytoskeletion
35
Q

examples of how singlaing pathways are complex integrated cell processing pathways

A
  • branch points for multiple responses
  • cross talk; integration of multiple signals
  • reciprocal communication/ induction