differential gene expression Flashcards
1
Q
development
A
- a sequence of changes in gene expression that alter cell behaviors which underlie morphogenesis
(cascade of gene expression) - signal transduction
2
Q
signal transduction
A
- driver of differential gene expression and changes in cell behavior/ morphogenesis
3
Q
differential gene expression
A
- the mechanism of cell differentiation
- accomplished by multiple layers of regulation (hierarchy of regulation)
- cascades of TF’s = cascades of gene expression (sequential activation of TFs)
4
Q
cell behaviors
A
- division, apoptosis, shape change, adhesiveness, intercalation, migration, signaling
- shape change
5
Q
changes in cell adhesion
A
- EMT require a loss of adhesiveness
- cells acquire different types of adhesion, allows to specifically adhere to each other and form tissue
6
Q
EMT are important for
A
- cancer
- development
- wound healing
- metastasis
7
Q
differential cell affinity
A
- see figure
- 1 type of adhesion cell + another type –> mix, creates segregation of cell types (inner and outer)
8
Q
cadherins
A
- large family of membrane proteins
- calcium dependent cell adhesion proteins
- homotypic binding specificity
- involved in morpho-regulatory processes… tissue boundaries, rearrangement, cell differentiation and metastasis
9
Q
intercalation
A
- cells move in between adjacent cells
- stay epithelial
10
Q
invagination
A
- infolding of a sheet of cells, indenting(draw)
- CHANGE CELL SHAPE
11
Q
involution
A
- during gastrulation
- inturning/inward movement of an expanding outer layer
- spreads over internal surface of remaining external cells (draw)
12
Q
epiboly
A
- over the ball
- growth of epidermal ectoderm to cover surface of embryo during gastrulation
13
Q
delamination
A
- splitting of one cellular sheet or layer into two parallel layers (draw)
14
Q
ingression
A
- migration of individual cells from surface layers into interior of embryo (draw)
- LOSS OF ADHESION
15
Q
convergent extension
A
- elongation of cell layer in one dimension and shortening in another dimension
- CELL SHAPE CHANGE / INTERCALATION
- primitive gut forming