developmental biology 1 Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

development of metazoans (multicelluar) includes:

A
  • gametogenesis
  • fertilization
  • embryonic period
  • fetal period
  • growth
  • later development
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

gametogenesis

A
  • formation of gametes: egg and sperm
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

fertilization

A
  • fusion of male and female gametes to form a zygote
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

embryonic period:

A
  • first 8 weeks of human development
  • formation of all precursors
  • developing organism = embryo
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

embryonic age vs gestational age

A
  • gestational: time that has passed since onset of last menstruation
  • embryonic: measures the actual age of the embryo or fetus from the time of fertilization
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

describe the fetal period

A
  • prenatal period between embryonic stage and birth; fetus; extensive growth and continued development of organ systems
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

describe the fetal period in organisms other than mammals

A
  • replaced with larval stages, followed by metamorphosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

describe the growth period

A
  • neonatal and child development period
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

describe later “development” period

A
  • tissue maintenance
  • wound healing
  • aging
  • cancer/diseases related to development
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

draw the fertilization age scale

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is required for embryonic development?

A
  • cell proliferation
  • cell differentiation
  • pattern formation and morphogenesis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is the cell cycle?

A
  • sequences of stages through which a cell passes between one cell division and the next
  • G1, S, G2, mitosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are checkpoints in the cell cycle?

A
  • cells make a decision about moving forward in the cell cycle
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

G1/R checkpoint (general)

A
  • trying to decide if cell cycle should continue
  • monitoring external/internal conditions
  • monitoring DNA damage
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

S/G2 and M phase checkpoint

A
  • constant monitoring of internal conditions…
  • S: if replication is complete… if DNA has been screened to remove error
    G2: cell size adequate… chromo replication complete
  • monitoring status of DNA… is it being replicated properly
    M monitoring mitotic spindle is properly formed
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

G1 checkpoint cells are responsive to…

A
  • nutrient levels
  • anchorage dependence
  • mitogenic growth factors
  • anti-mitogenic TGF- beta signals
17
Q

Choices prior to / at R checkpoint:

A
  • remain in active proliferation
  • exit cell cycle (G0 or post-mitotic phase)
  • apoptosis
18
Q

What has the cell committed to after completing R checkpoint?

A
  • completing the cell cycle
  • if deregulated, becomes cancer
19
Q

G0 phase in detail

A
  • monitor external/internal conditions
  • 3 states:
  • reversible
    1. Quiescent: resting, inactive
  • irreversible
    2. Senescent (not really resting or active.. dont die but dont rlly do anything)
    3. Differentiated (not inactive)
    terminally differentiated cells such as nerve and muscle cells
20
Q

What are the two types of genes that regulate the cell cycle?

A
  • proto-oncogenes
  • tumor suppressors
21
Q

proto-oncogenes

A
  • stimulate cell cycle progression
  • mutation in cancer: gain of function
  • proto-oncogene = wt; oncogene = mutant
22
Q

tumor suppressors

A
  • inhibit cell cycle progression
  • mutation in cancer: loss of function
23
Q

why is maintaining genome integrity important?

A
  • to make sure daughter cells dont inherit damages DNA
24
Q

What gene is activated in response to DNA damage

A
  • tumor supressor p53
25
Q

what are the p53 pathways responsible for?

A
  • halting the cell cycle until damage is repaired
  • initiating apoptosis
26
Q

What is p53 pathway? (draw )

A

27
Q

why are CDK and cyclins important?

A
  • CDK phosphorylates, and are dependent on the presence of cyclin
  • regulate passage through the checkpoints
28
Q

cell cycle regulation pathways converging on the R checkpoint

A

mitogen –> cyclin –> CDK –> repress pRb… unless repressed by Growth factors….
pRb is repressed due to phosphorylation