shockry-autacoids Flashcards

1
Q

what are the two serotonin agonists?

A

cisapride

**fluoxetine **-prozac

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2
Q

which serotonin agonist is a prokinetic and works through the entire GI tract?

A

cisapride

** **it is a 5-HT4R agonist in enteric neurons

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3
Q

what are the clinical uses of fluoxetine?

A
  • txt of canine separation anxity
  • txt of behavior disorders- aggression, OCD, anxiety
  • can be used transdermal in cats
  • use with cats that have elimination and urine making probs
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4
Q

what is the MOA of fluoxetine?

A

increase serotonin levels in the brain (improves signs of depression in human)

it is a Serotonin specific reuptake inhibitor (SSRI) so it wont break down and will stay around longer

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5
Q

what are the serotonin antagnosists?

A
  • cyproheptadine
  • ondansetron
  • metoclopramide
  • mirtazapine
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6
Q

what serotinin antagonist can be used to t_xt serotonin syndrome_ and stimulate appetite in small animals

A

cyproheptadine

it blockes H1 and serotonin R which inhibits ACTH

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7
Q

what serotonin antagonist is prevention and txt of anticancer chemotherapy-induce nausea and vom?

A

Ondansetron

MOA: 5HT receptor antagonist (central and peripheral)

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8
Q

at a high dose this 5HT receptor antagonist can be used as an anti-emetic centrally

A

metoclopramide

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9
Q

at a low dose this _D1 & D2 receptor antagnos_t can be used a prokinetic peripherally

A

metoclopramide

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10
Q

which serotonin antagonist is a TCA antidepressant and an anti-emetic

A

mirtazapine

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11
Q

what drug blocks NK1 receptors preventing substace P form binding resulting in an anti-emeic effect?

A

Maropitant

classified as a neurokinin antagonist

prevents vom due to motion sickness as well as vom due to viral infx

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12
Q

what can inhibit secretionof renin?

A
  • Ang 2
  • ADH
  • hypertension
  • increased reabsorption of Na
  • B1-adrenergic blockers
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13
Q

what **stimulates secretion **of renin?

A
  • hypotension
  • decreased renal blood flow
  • low Na or Cl in blood
  • sympathetic stim
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14
Q

**angiotensin II ** stimulates _____secretion and inhibits _____ release.

A

stimulates ALD secretion

inhibits r_enin release_

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15
Q

what PG agonist is a synthetic PGE1that is used as an anti-ulcer txt?

A

misoprostol

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16
Q

what are the PG agonists that increase uveoscleral outflow by stimulting FP receptors?

A
  • Latanoprost
  • travopost
  • bimatoprost

they are topical txt for open-angle glaucome/ocular hypertension

17
Q

What are the PG inhibitors?

A
  • COX inhibitors (NSAIDS)
  • Phospholipase A2 inhibitors (corticosteroids also inhibit COX2)
18
Q

what are the two Leukotriene inhibitors?

A
  • zafirlukast
  • zileuton
19
Q

what leukotriene receptor antagonist prevents bronchoconstriction in cats?

A

zafirlukast

LOX already made, just block R

20
Q

which drug is a 5-Lipoxygenase inhibitor and prevents bronchoconstriction in cats?

A

zileuton

it inhibits leukotriene formation

21
Q

WTF is oclacitinib and what is it used for?

A
  • janus kinase inhibitor
  • use for control of puritis associated allergic and atopic dermatitis
22
Q
A