shockry-autacoids Flashcards
what are the two serotonin agonists?
cisapride
**fluoxetine **-prozac
which serotonin agonist is a prokinetic and works through the entire GI tract?
cisapride
** **it is a 5-HT4R agonist in enteric neurons
what are the clinical uses of fluoxetine?
- txt of canine separation anxity
- txt of behavior disorders- aggression, OCD, anxiety
- can be used transdermal in cats
- use with cats that have elimination and urine making probs
what is the MOA of fluoxetine?
increase serotonin levels in the brain (improves signs of depression in human)
it is a Serotonin specific reuptake inhibitor (SSRI) so it wont break down and will stay around longer
what are the serotonin antagnosists?
- cyproheptadine
- ondansetron
- metoclopramide
- mirtazapine
what serotinin antagonist can be used to t_xt serotonin syndrome_ and stimulate appetite in small animals
cyproheptadine
it blockes H1 and serotonin R which inhibits ACTH
what serotonin antagonist is prevention and txt of anticancer chemotherapy-induce nausea and vom?
Ondansetron
MOA: 5HT receptor antagonist (central and peripheral)
at a high dose this 5HT receptor antagonist can be used as an anti-emetic centrally
metoclopramide
at a low dose this _D1 & D2 receptor antagnos_t can be used a prokinetic peripherally
metoclopramide
which serotonin antagonist is a TCA antidepressant and an anti-emetic
mirtazapine
what drug blocks NK1 receptors preventing substace P form binding resulting in an anti-emeic effect?
Maropitant
classified as a neurokinin antagonist
prevents vom due to motion sickness as well as vom due to viral infx
what can inhibit secretionof renin?
- Ang 2
- ADH
- hypertension
- increased reabsorption of Na
- B1-adrenergic blockers
what **stimulates secretion **of renin?
- hypotension
- decreased renal blood flow
- low Na or Cl in blood
- sympathetic stim
**angiotensin II ** stimulates _____secretion and inhibits _____ release.
stimulates ALD secretion
inhibits r_enin release_
what PG agonist is a synthetic PGE1that is used as an anti-ulcer txt?
misoprostol