shockry -anti fungals Flashcards
all of the following are effective against candida except?
a. griseofulvin
b. ketoconazole
c. nystatin
d. amphotericin B
e. flycytosine
griseofulvin
which of the following should not be used in severe, acute, systemic fungal infections?
a. griseofulvin
b. ketoconazole
c. nystatin
d. amphotericin B
e. flycytosine
nystatin
a systemic antifungal which penetrates into the CNS and is DOC for treating cryptococcal meningitits is?
a. nystatin
b. amphotericin B
c. fluconazole
d. griseofulvin
e. ketoconazole
fluconazole
griseofulvin :
a. exerts a detergent like effect on hyphae membranes
b. must be given parenterally since oral is poor
c. if frequently combo with ab to pevent yeast infections in gut
d. particularly effective against dermatophyte infections
e. b and d
particularly effective against dermatophyte infections
GIVEN ONLY ORALLY*
what is the main disadvantage of amphotericin B in therapy of systemic mycosis?
nephrotoxicity
nystain:
a. is given orally for generalized ringworm infections as alternate to griseofulvin
b. combo with fluocytosine for systemic mycosis
c. primarily used in mucosal yeast infections caused by candida
d. a fungistatic imidazole related to ketoconazole
primarily used in mucosal yeast infections caused by candida
which is LEAST accurate about griseofulvin?
a. effective against microsporum, tricho and candida
b. has to be given orally
c. given daly for 3-6 weeks to be effective
d. slow fungistatic action
e. enzyme inducer
effective against microsporum, tricho and candida
all of the following are true about ketoconazole EXCEPT
a. at high doses cause suppression of the adrenal cortex in dogs and cats
b. absorbed orally and is widely distributed to CNS
c. may cause GI irritation
d. inhibits synthesis of ergosterol of fungal cell membrane
e. used to treat systemic mycoses and several yeast infx
absorbed orally and is widely distributed to CNS
what is the DOC for controlling severe, fulminating, systemic mycosis?
amphotericin B
which is the most effective against aspergillus?
a. amphotericin B
b. ketoconazole
c. itraconazole
d. fluconazole
e. griseofulvin
itraconazole
when used amphotericin B, what is the most important thing to do?
monitor kidney function because its nephrotoxic
how does nystatin work?
binds to sterols in the membrane of fungi
T/F ketoconazole achieves therapeutic levels in the brain?
FALSE
the following are used topically or locally because they are too toxic for systemic use except?
a. bacitracin
b. polymixin B
c. neomycin
d. thiabendazole
e. nystin
thiabendazole
