Sexual dysfunction

Question 1

Receptor thought to mediate the erectile dysfunction side effects of antipsychotics

Answer 1

Cholinergic receptor antagonism

Question 2

Causes of sexual dysfunction in antipsychotic use

Answer 2

Due to elevated prolactin levels

Anticholinergic and antiadrenergic effects independent of prolactin levels

Question 3

Antipsychotics with the greatest impact on sexual function

Answer 3

Risperidone/paliperidone

Haloperidol

Question 4

Percentage of patients taking haloperidol and risperidone/paliperidone who report sexual dysfunction

Answer 4

70%

Question 5

Antipsychotics with lowest sexual dysfunction effects

Answer 5

Aripiprazole
Asenapine
Lurasidone

Question 6

Scale used in asking about sexual dysfunction

Answer 6

Arizona sexual experiences scale

Question 7

Five areas of sexual dysfunction measured in the Arizona sexual experiences scale

Answer 7

Sexual drive
Arousal
Penile erection/vaginal lubrication
Ability to orgasm
Satisfaction from orgasm

Question 8

Antidepressant classes with the greatest impact on sexual function

Answer 8

SSRIs
MAOIs
SNRIs
TCAs

Question 9

Antidepressants with the lowest impact on sexual function

Answer 9

Reboxetine
Moclobemide
Mirtazapine
Agomelatine
Bupropion

Question 10

Antipsychotic to consider adding if patient is experiencing antipsychotic related sexual dysfunction

Answer 10

Aripiprazole

Question 11

Presumed mechanism of sexual dysfunction with SSRIs

Answer 11

5HT2 agonism

Question 12

Class of medications including buspirone which can be used to reverse SSRI related sexual dysfunction

Answer 12

5HT1A agonists