History of pharmacology

Question 1

Coined the term psychopharmacology

Answer 1

Macht and Mora

Question 2

Reported on antipsychotic properties of the plant Rauwolfia serpentine

Answer 2

Sen and Bose

Question 3

Discovered the use of lithium in mania

Answer 3

Cade

Question 4

Showed the antipsychotic effects of chlorpromazine (previously used presurgically)

Answer 4

Delay and Deniker

Charpentier (two teams discovered independently)

Question 5

First antidepressant to be discovered

Answer 5

Iproniazid

Question 6

Reason iproniazid was discontinued

Answer 6

Hypertensive reactions

Question 7

First synthesised chlorpromazine

Answer 7

Charpentier

Question 8

Reintroduced clozapine

Answer 8

Kane

Question 9

Developed the first SSRI zimelidine

Answer 9

Carlsson

Question 10

First discovered the ‘cheese effect’ in MAOIs

Answer 10

Blackwell

Question 11

Second antidepressant to market

Answer 11

Imipramine

Question 12

Discovered the antidepressant use for imipramine

Answer 12

Kuhn

Question 13

First to use ECT

Answer 13

Cerletti and Bini

Question 14

Coined the term ‘antidepressant’

Answer 14

Lurie

Question 15

First to use insulin shock therapy

Answer 15

Sakel

Question 16

First to use frontal lobotomy for psychosis

Answer 16

Moniz

Question 17

First to use metrazol shock therapy

Answer 17

Meduna

Question 18

First SSRI to be developed

Answer 18

Zimeldine

Question 19

Drug clozapine was synthesised from

Answer 19

Imipramine

Question 20

Synthesised haloperidol and risperidone

Answer 20

Janssen

Question 21

Year the first true antidepressant was discovered

Answer 21

1952

Question 22

Year in which use of lithium in mania was discovered

Answer 22

1949

Question 23

Years in which antipsychotic effects of chlorpromazine were discovered

Answer 23

1950-1952

Question 24

Discovered the first benzodiazepine

Answer 24

Sternbach

Question 25

First benzodiazepine to be discovered

Answer 25

Chlordiazepoxide

Question 26

Year fluoxetine was marketed

Answer 26

1987

Question 27

Coined the term ‘neuroleptic’

Answer 27

Delay

Question 28

Study in 1988 which led to the widespread use of clozapine

Answer 28

Clozaril Collaborative Study Group Study #30

Question 29

Results of the Clozaril Collaborative Study Group Study #30 in 1988 among patients with treatment resistant psychosis

Answer 29

30% of clozapine patients responded

4% of controls responded

Question 30

Two large scale trials comparing first generation and second generation antipsychotics

Answer 30

CATIE

CUtLASS

Question 31

Findings of the CATIE and CUtLASS studies

Answer 31

Second generation antipsychotics do not markedly differ from first generation antipsychotics in compliance, quality of life or effectiveness

Question 32

Prevalence of metabolic syndrome among patients on antipsychotic in the CATIE trial

Answer 32

41%

Question 33

Prevalence of metabolic syndrome among women on antipsychotics in the CATIE trial

Answer 33

52%

Question 34

Prevalence of metabolic syndrome among men on antipsychotics in the CATIE trial

Answer 34

36%

Question 35

Typical antipsychotic used in the CATIE trial

Answer 35

Perphenazine

Question 36

Four atypical antipsychotics used in the CATIE trial

Answer 36

Olanzapine
Quetiapine
Risperidone
Ziprasidone

Question 37

Year clozapine was first synthesised

Answer 37

1958

Question 38

Reason clozapine was removed from market initially

Answer 38

Deaths from agranulocytosis

Question 39

Type of antidepressant iproniazid was

Answer 39

Monoamine oxidise inhibitor

Question 40

Type of antidepressant imipramine was

Answer 40

Tricyclic antidepressant

Question 41

Reasons zimeldine was removed from market

Answer 41

Hypersensitivity reactions

Guillain-Barré syndrome

Question 42

First scientist to quantify the placebo effect

Answer 42

Beecher

Question 43

Associated with the use of valproate in mania

Answer 43

Bowden

Question 44

Historically known as major tranquillisers

Answer 44

Antipsychotics

Question 45

Historically known as minor tranquillisers

Answer 45

Benzodiazepines, barbiturates