Sex hormones, DM Flashcards
Decreases plasma potassium
insulin
BPH
5 alpha reductase inhibitors
Major edema, contraindicated in CHF
Thiazolidnediones
DOC to induce labor at term
oxytocin
Use 7-10 days before thyroid surgery to decreased likelihood of thyroid storm
Iodine
May increase beta cell number and function
GLP-1 agonists
Most commonly prescribed oral glucocorticoid
Prednisone
4 things that cause uterine contractions
Estrogen
Prostaglandins
Oxytocin
Stretching
Use if the patient has a sulfa allergy in place of a sulfonylurea
Meglitinides
Can’t be used in combination due to similar MOAs
Sulfonylureas
Meglitinides
Addison’s disease
adrenal insufficiency: glucocorticoid +/- mineralocorticoid
Lupus
glucocorticoids
2nd line postpartum hemorrhage/1st line drug
Ergot alkaloids
Allergic reactions
glucocorticoids
DOC for estrogen dependent breast cancer in PREmenopausal women
Tamoxifen
estrogen antagonist in breast tissue
insulin independent decrease in glucose levels: can use if no functioning beta cells
Metformin
ONLY diabetic oral agent that can also be used to treat T1DM
Amylin
4 things that cause uterine relaxation
Beta agonists
Progesterone
Alcohol
MgSO4
Can be used off label for T1DM
Alpha glucosidase inhibitors
Shock (esp anaphylactic)
glucocorticoids
Similar to tamoxifen and increases HDL
Toremifene
Prophylaxis for breast cancer
Tamoxifen
2nd line for advanced breast cancer in postmenopausal women if disease progressed during Tamoxifen therapy
Exemestane (irreversible aromatase inhibitor)
Hypoaldosteronism/adrenal insufficiency refractory to glucocorticoids alone
Fludrocortisone: for salt and water retention
If a premenopausal women is refractory to Tamoxifen
Perform radioablation of ovaries, then use Exemestane (irreversible aromatase inhibitor)
Adverse effect: lactic acidosis
metformin
PMS
Spironolactone?
Can only be given as an adjunct to insulin therapy
Amylin
Most damaging and therapeutically limiting effect of glucocorticoids
Osteoporosis
To hasten fetal lung development if a baby is going to be born prematurely (before 37 weeks)
cortisol
Delay carbohydrate digestion/absorption: weight loss
Alpha glucosidase inhibitors
oral contraceptive best for adolescents whose epiphyseal plate is still open
mini pill
Short term use while cause of Cushing’s is being discovered
Metyrapone: ~selective~ inhibitor of enzyme in cortisol synthesis
Treat endometriosis
Danazol
DOC for Grave’s
Methimazole
Give for 9-12 days during the follicular phase in IVF to stimulate the ovaries to produce estrogen
hMG (FSH actions)
FDA approved to prevent convulsions in preeclampsia/ treat eclampsia
MgSO4 (magnesium sulfate)
Expulsion of uterine contents due to fetal death, miscarriage, abortion
Dinoprostone suppository inserted into vaginal every 3-5 hours
FDA approved to prevent premature labor
none of the tocolytic drugs
Male pattern baldness
5 alpha reductase inhibitors
Lowering LDL and total cholesterol in postmenopausal women
Raloxifene (E agonist in liver)
A patient needs glucocorticoids but has liver failure
Give hydrocortisone or prednisolone, don’t have to be converted to active form by liver
Hirsutism, PMS
Spironolactone
Use when estrogen in contraindicated
Progestins
Initial treatment of hyperthyroidism while waiting for meds to take full effect/surgery
Propranolol
Myxedema coma DOC
Inject T3
Corticosteroids