NSAIDS, GI Flashcards
1
Q
Analgesic for active PUD
A
acetaminophen or opioids (codeine)
2
Q
Best for UC (IBD)
A
Sulfasalazine (5-aminosalicylic acid plus sulfapyridine)
3
Q
Rescue inhaler
A
Short acting Beta 2 agonists
4
Q
Decreasing aspirin sensitive asthma
A
Zileuton (leukotriene inhibitor)
5
Q
OTC osmotic laxative for occasional constipation
A
Miralax (polyethylene glycol)
6
Q
Most potent NSAIDs, but have the worst side effects
A
Indomethacin
Phenylbutazone
7
Q
Reduces pain and inflammation in acute gout attacks
A
Colchicine
8
Q
To rapidly clear stomach contents
A
Erythromycin
9
Q
Antidote to Acetaminophen intoxication
A
N-acetylcysteine
administered parenterally within 10-12 hours
10
Q
DOC NSAID for gout
A
Indomethacin
11
Q
Chronic use causes vasoconstriction and CNS effects
A
Ergotism (St anthony’s fire)
12
Q
Make your tongue and stool black
A
Bismuth subsalicylate
13
Q
Can cause severe hypersensitivity because the enzyme is not found in humans
A
Urate oxidase enzymes: Rasburicase Pegloticase (presumably)
14
Q
Analgesic if no history of PUD
A
NSAID
15
Q
To prevent or reduce NSAID-induced damage
A
Misoprostol
16
Q
Give in patients that had an inadequate response or intolerance to methotrexate
A
Tofacitinib
17
Q
Reduce absorption of aspirin
A
Antacids
18
Q
NSAID for closing the patent ductus arteriosus
A
Indomethacin
19
Q
Used in combination with 5HT3 antagonists (“setrons”)
A
NK1 antagonist→ Aprepitant
20
Q
Long term use decreases colon cancer
A
Aspirin
21
Q
Used for IBS
A
Antispasmodics
22
Q
Very intense mucosal agent
A
Castor oil
23
Q
Used for surgery, diagnostic
A
Castor oil
24
Q
Reduce inflammation in IBD
A
Corticosteroids
25
Migraine prophylaxis
Beta-Blockers→ Propranolol
Calcium Channel Blockers→ Verapamil
Antidepressants
•Amitriptyline (Elavil, Endep)
•Fluoxetine (Prozac)
```
Clonidine
Valproic Acid
Topiramate (antiepileptic)
Botulinum Toxin Type A+B
Angiotensin II receptor blockersk
```
26
Increase lower esophageal sphincter tone
Bethanechol
27
Most widely used treatment for asthma
Short acting Beta 2 agonists
28
For severe, refractory IBD
Infliximab, adalimumab
| TNF-alpha blockers
29
Give prophylactic colchicine therapy as it can trigger an attack
Xanthine oxidase inhibitors:
Allopurinol
Febuxostat
30
Utilized for removal of warts, corns, fungal infection, eczematous dermatitis
Salicylic acid (but not aspirin)
31
Can be used for hirsutism
Cimetidine
| avoid in males
32
NSAID with the longest half life
Naproxen
33
2 best drugs for motion sickness
Dimenhydrinate
| Scopolamine
34
Treat or prevent ulcers
H2 antagonists
35
Prep for colonoscopy
Large volume of polyethylene glycol (osmotic laxative) with electrolytes
36
***Analgesic if history of PUD, but not currently active***
Celecoxib +/- antacids
NSAIDs + misoprostol or prazoles (PPIs)
37
Good for antinausea from chemo/radiation, but not good for motion sickness
5HT3 antagonists
| "setrons"
38
Other NSAIDs for gout
Naproxen
Celecoxib
Sulindac
39
When it comes to chemotherapy, allopurinol increases the effects of ______ and decreases the effect of _______
Increases: mercaptopurines 6-MP and azathioprine
Blocks activation, decreases: Fluorouracil (5 FU)
40
Prevention, prophylaxis, and decreasing nocturnal asthma.
| Always combined with a steroid
Long acting Beta 2 agonists
41
Expensive, only used for refractory migraine therapy
Triptans
42
Combined with a xanthine oxidase inhibitor
Lesinurad
43
Drug of last choice for asthma because of an FDA black box warning about increased death
Long acting beta 2 agonists, study was done on drugs not combined with steroids
44
Antihistamines for sedation
Diphenydramine
Doxylamine
Hydroxyzine
45
Also used for Wilson's disease
Penicillamine
46
Post-op ileus
Bethanechol
47
Caution using this analgesic in children (liver toxicity), but often used to reduce fever in children
Acetaminophen
48
DMARD (JAK kinase inhibitor) that can be used in monotherapy or in combination with methotrexate or non-biologic DMARDS
Barcinitib
49
Mild mucosal agents (2)
Bisacodyl
| Senna
50
Effective in primary and secondary gout
Xanthine oxidase inhibitors:
Allopurinol
Febuxostat
51
Drug of last choice for refractory asthma or COPD
Theophylline
52
IV only, similar to ergotamine but more effective
Dihydroergotamine
53
DOC among NSAIDs as it has the best side effects profile
Ibuprofen
54
Post-op analgesia
Ketorelac
55
For ulcers refractory to H2A
PPIs
56
MI and thrombosis prophylaxis
Aspirin
57
The best drugs for motion sickness
Dimenhydrinate (1st gen antihistamine)
Scopolamine (antimuscarinic, not discussed this unit)
58
While using this DMARD, you have to monitor for hepatitis and bone marrow suppression
(q 2-3 weeks x3 months, then periodically)
Sulfasalazine
59
Antihistamines for motion sickness prophylaxis
1st gen:
Diphenhydramine
Doxylamine
Promethazine
60
Antiemetic antihistamine
Promethazine
61
Use in patients on chronic NSAID therapy to prevent adverse GI effects
PPIs
62
Diabetic gastroparesis
Erythromycin
63
H pylori therapy to block acid and kill bacteria (4)
* Pepto-Bismol
* Metronidazole
* ABX: Clarithromycin, tetracycline, amoxicillin
* H2 blocker
64
Can be used for preanesthesia
H2 antagonists
65
DOC Zollinger- Ellison
PPIs
66
Antispasmodic for IBS-D
Eluxadoline (opioid agonist)
67
Severe allergic reactions should get
Both an H1 (antihistamines) and an H2 blocker ("tidines")
68
Decreases the absorption of allopurinol
***
Aluminum hydroxide
***
69
Give before starting chemotherapy to prevent a gout attack triggered by tumor lysis syndrome
Rasburicase
70
Temporary relief of heartburn or gastritis, adjunct therapy
Antacids
71
For IBS-C
Linaclotide
72
Mostly used for asthma in children
Cromolyn sodium, nedocromil
73
Antiemetic used in combination with 5HT3
Aprepitant (NK1 antagonist)
74
Analgesics for migraines
Aspirin
Acetaminophen
Naproxen
Propoxyphene
75
Antihistamines for a patient with liver failure
Those excreted by kidneys:
Cetirizine
Levocetirizine
Acrivastine
76
Best adverse affect profile: Acetaminophen vs ibuprofen
Acetaminophen
77
Moderate to severe *allergic* asthma
Omalizumab
78
Small bowel dysmotility
Erythromycin
79
Used to stimulate appetite in chemo patients (and reduce nausea)
Cannabinoids
| Dronabinol/THC
80
DMARD that is also used for refractory Non-Hodgkin's lymphoma
Rituximab
| Specifically blocks CD20 antigen expressed on B-cells in non-Hodgkin's lymphoma.
researching other cancers
81
NSAID with uricosuric effects
Aspirin
82
Prevention of hepatic encephalopathy in those with cirrhosis or liver disease
Lactulose
83
TNF alpha inhibitor approved for monotherapy
| most DMARDs combined with methotrexate
Adalimumab
84
Combined with codeine and derivatives, sedatives, cough
| suppressants, tramadol, diphenhydramine, caffeine
Acetaminophen
85
DOC for GERD with esophagitis
PPIs
86
TNF alpha inhibitor that also treats Crohn's disease
Infliximab
