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DOCs/Indications > NSAIDS, GI > Flashcards

NSAIDS, GI Flashcards

1
Q

Analgesic for active PUD

A

acetaminophen or opioids (codeine)

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2
Q

Best for UC (IBD)

A

Sulfasalazine (5-aminosalicylic acid plus sulfapyridine)

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3
Q

Rescue inhaler

A

Short acting Beta 2 agonists

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4
Q

Decreasing aspirin sensitive asthma

A

Zileuton (leukotriene inhibitor)

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5
Q

OTC osmotic laxative for occasional constipation

A

Miralax (polyethylene glycol)

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6
Q

Most potent NSAIDs, but have the worst side effects

A

Indomethacin

Phenylbutazone

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7
Q

Reduces pain and inflammation in acute gout attacks

A

Colchicine

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8
Q

To rapidly clear stomach contents

A

Erythromycin

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9
Q

Antidote to Acetaminophen intoxication

A

N-acetylcysteine

administered parenterally within 10-12 hours

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10
Q

DOC NSAID for gout

A

Indomethacin

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11
Q

Chronic use causes vasoconstriction and CNS effects

A

Ergotism (St anthony’s fire)

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12
Q

Make your tongue and stool black

A

Bismuth subsalicylate

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13
Q

Can cause severe hypersensitivity because the enzyme is not found in humans

A 
Urate oxidase enzymes:
Rasburicase
Pegloticase (presumably)
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14
Q

Analgesic if no history of PUD

A

NSAID

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15
Q

To prevent or reduce NSAID-induced damage

A

Misoprostol

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16
Q

Give in patients that had an inadequate response or intolerance to methotrexate

A

Tofacitinib

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17
Q

Reduce absorption of aspirin

A

Antacids

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18
Q

NSAID for closing the patent ductus arteriosus

A

Indomethacin

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19
Q

Used in combination with 5HT3 antagonists (“setrons”)

A

NK1 antagonist→ Aprepitant

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20
Q

Long term use decreases colon cancer

A

Aspirin

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21
Q

Used for IBS

A

Antispasmodics

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22
Q

Very intense mucosal agent

A

Castor oil

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23
Q

Used for surgery, diagnostic

A

Castor oil

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24
Q

Reduce inflammation in IBD

A

Corticosteroids

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25
Q

Migraine prophylaxis

A

Beta-Blockers→ Propranolol

Calcium Channel Blockers→ Verapamil

Antidepressants
•Amitriptyline (Elavil, Endep)
•Fluoxetine (Prozac)

Clonidine
Valproic Acid
Topiramate (antiepileptic) 
Botulinum Toxin Type A+B
Angiotensin II receptor blockersk
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26
Q

Increase lower esophageal sphincter tone

A

Bethanechol

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27
Q

Most widely used treatment for asthma

A

Short acting Beta 2 agonists

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28
Q

For severe, refractory IBD

A

Infliximab, adalimumab

TNF-alpha blockers

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29
Q

Give prophylactic colchicine therapy as it can trigger an attack

A

Xanthine oxidase inhibitors:
Allopurinol
Febuxostat

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30
Q

Utilized for removal of warts, corns, fungal infection, eczematous dermatitis

A

Salicylic acid (but not aspirin)

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31
Q

Can be used for hirsutism

A

Cimetidine

avoid in males

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32
Q

NSAID with the longest half life

A

Naproxen

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33
Q

2 best drugs for motion sickness

A

Dimenhydrinate

Scopolamine

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34
Q

Treat or prevent ulcers

A

H2 antagonists

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35
Q

Prep for colonoscopy

A

Large volume of polyethylene glycol (osmotic laxative) with electrolytes

36
Q

Analgesic if history of PUD, but not currently active

A

Celecoxib +/- antacids

NSAIDs + misoprostol or prazoles (PPIs)

37
Q

Good for antinausea from chemo/radiation, but not good for motion sickness

A

5HT3 antagonists

“setrons”

38
Q

Other NSAIDs for gout

A

Naproxen
Celecoxib
Sulindac

39
Q

When it comes to chemotherapy, allopurinol increases the effects of ______ and decreases the effect of _______

A

Increases: mercaptopurines 6-MP and azathioprine

Blocks activation, decreases: Fluorouracil (5 FU)

40
Q

Prevention, prophylaxis, and decreasing nocturnal asthma.

Always combined with a steroid

A

Long acting Beta 2 agonists

41
Q

Expensive, only used for refractory migraine therapy

42
Q

Combined with a xanthine oxidase inhibitor

43
Q

Drug of last choice for asthma because of an FDA black box warning about increased death

A

Long acting beta 2 agonists, study was done on drugs not combined with steroids

44
Q

Antihistamines for sedation

A

Diphenydramine
Doxylamine
Hydroxyzine

45
Q

Also used for Wilson’s disease

A

Penicillamine

46
Q

Post-op ileus

A

Bethanechol

47
Q

Caution using this analgesic in children (liver toxicity), but often used to reduce fever in children

A

Acetaminophen

48
Q

DMARD (JAK kinase inhibitor) that can be used in monotherapy or in combination with methotrexate or non-biologic DMARDS

A

Barcinitib

49
Q

Mild mucosal agents (2)

A

Bisacodyl

Senna

50
Q

Effective in primary and secondary gout

A

Xanthine oxidase inhibitors:
Allopurinol
Febuxostat

51
Q

Drug of last choice for refractory asthma or COPD

A

Theophylline

52
Q

IV only, similar to ergotamine but more effective

A

Dihydroergotamine

53
Q

DOC among NSAIDs as it has the best side effects profile

54
Q

Post-op analgesia

55
Q

For ulcers refractory to H2A

56
Q

MI and thrombosis prophylaxis

57
Q

The best drugs for motion sickness

A

Dimenhydrinate (1st gen antihistamine)

Scopolamine (antimuscarinic, not discussed this unit)

58
Q

While using this DMARD, you have to monitor for hepatitis and bone marrow suppression

(q 2-3 weeks x3 months, then periodically)

A

Sulfasalazine

59
Q

Antihistamines for motion sickness prophylaxis

A

1st gen:
Diphenhydramine
Doxylamine
Promethazine

60
Q

Antiemetic antihistamine

A

Promethazine

61
Q

Use in patients on chronic NSAID therapy to prevent adverse GI effects

62
Q

Diabetic gastroparesis

A

Erythromycin

63
Q

H pylori therapy to block acid and kill bacteria (4)

A
  • Pepto-Bismol
  • Metronidazole
  • ABX: Clarithromycin, tetracycline, amoxicillin
  • H2 blocker
64
Q

Can be used for preanesthesia

A

H2 antagonists

65
Q

DOC Zollinger- Ellison

66
Q

Antispasmodic for IBS-D

A

Eluxadoline (opioid agonist)

67
Q

Severe allergic reactions should get

A

Both an H1 (antihistamines) and an H2 blocker (“tidines”)

68
Q

Decreases the absorption of allopurinol

A

Aluminum hydroxide
***

69
Q

Give before starting chemotherapy to prevent a gout attack triggered by tumor lysis syndrome

A

Rasburicase

70
Q

Temporary relief of heartburn or gastritis, adjunct therapy

71
Q

For IBS-C

A

Linaclotide

72
Q

Mostly used for asthma in children

A

Cromolyn sodium, nedocromil

73
Q

Antiemetic used in combination with 5HT3

A

Aprepitant (NK1 antagonist)

74
Q

Analgesics for migraines

A

Aspirin
Acetaminophen
Naproxen
Propoxyphene

75
Q

Antihistamines for a patient with liver failure

A

Those excreted by kidneys:
Cetirizine
Levocetirizine
Acrivastine

76
Q

Best adverse affect profile: Acetaminophen vs ibuprofen

A

Acetaminophen

77
Q

Moderate to severe allergic asthma

A

Omalizumab

78
Q

Small bowel dysmotility

A

Erythromycin

79
Q

Used to stimulate appetite in chemo patients (and reduce nausea)

A

Cannabinoids

Dronabinol/THC

80
Q

DMARD that is also used for refractory Non-Hodgkin’s lymphoma

A

Rituximab

Specifically blocks CD20 antigen expressed on B-cells in non-Hodgkin’s lymphoma.
researching other cancers

81
Q

NSAID with uricosuric effects

82
Q

Prevention of hepatic encephalopathy in those with cirrhosis or liver disease

83
Q

TNF alpha inhibitor approved for monotherapy

most DMARDs combined with methotrexate

A

Adalimumab

84
Q

Combined with codeine and derivatives, sedatives, cough

suppressants, tramadol, diphenhydramine, caffeine

A

Acetaminophen

85
Q

DOC for GERD with esophagitis

86
Q

TNF alpha inhibitor that also treats Crohn’s disease

A

Infliximab

DOCs/Indications (7 decks)

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