Session 2- Renal Clearance Flashcards
How is kidney function measured
Glomerular filtration rate
what is GFR
Amount of filtrate that is produced from the blood flow
What does a decrease in GFR indicate
Kidney function has worsened due to
- decline in number of nephrons
- decline in GFR within individual nephrons
What occurs when kidney function declines slowly
Individual nephrons may hypertrophy so actua kidney function may not fall until significant kidney damage
What is clearance
Volume of plasma that is cleared of a substance in a unit of time. As measurement of the kidneys ability to move a substance from the plasma and excrete it
when does nephron development finish
35th-36th week of feral development
What happens to GFR after 30 years
Starts to decline- some compensatory hypertrophy
What happens to GFR in pregnancy
Increases
Kidney size increases
What is needed to measure true GFR
- Be produced at a constant rate
- Be freely filtered across the glomerulus
- Not be reabsorbed in the nephron
- Not be secreted into the nephron
Why don’t we use inulin to measure GFR
Requires continuos IVI to maintain steady state
Requires catheter and timed urine collections
What is used instead fo inulin
51 CR-EDTA
