Session 2 - Acute Inflammation Flashcards
Give five causes of acute inflammation
- Microbial infections e.g. pyogenic organisms
- Hypersensitivity reactions
- Physical agents e.g. heat and trauma
- Chemicals
- Tissue necrosis – elicits inflammatory reaction
What is the purpose of acute inflammation?
To limit disease process
Give the five symptom of acute inflammation
- Rubor – redness
- Tumor – swelling
- Calor – heat
- Dolor – pain
- Loss of sensation
Give four microscopic features of acute inflammation
Tissue oedema
Neturophil margination and emigration
Dead myocytes
Neutrophils
What is the purpose of oedema? (3)
Delivers plasma proteins to site of injury
Dilutes toxins
Increases lymphatic drainage
Give three plasma proteins involved in oedema
Immunoglobulins, inflammatroy mediators, fibrinogen
What is the purpose of vasodilation?
Increases delivery and temperature
What is the purpose of neutrophil margination and emigration into site of inflammation?
Removes pathogenic organisms and necrotic debris
Explain how rubor relates to microscopic changes
Vasodilation
How is tumour caused?
Oedema/infiltration of neutrophils
How is calor caused?
Vasodilation
How is dolor caused?
- Dolor – result of chemical mediators e.g. bradykinin is also involved in the pain mechanism > dolor enforces rest > reduces chance of further traumatic damage
