Serotonin HT3R & Glycine Receptor

Question 1

Serotonin aka?

Answer 1

1. Enteromine

2. 5-hydroxytryptomine

Question 2

Serotonin HT3R is a?

Answer 2

Heteropentamer

Question 3

HT3R agonist

Answer 3

2-methyl serotonin

Question 4

HT3R antagonists

Answer 4

1. Dolasetron
2. Ondasetron
3. Granisetron
4. Palonosetron
5. . Alosetron (withdrawn)

Question 5

Serotonin-gated channels are excitatory/inhibitory

Answer 5

Excitatory

Question 6

Excitatory channels have what effect on membrane potential?

Answer 6

Strongly depolarizing

Question 7

Glycine receptor is a?

Answer 7

Heteropentamer

Question 8

Glycine receptor has how many alpha subunit?

Answer 8

3 (so 3 binding sits)

Question 9

Glycine receptor agonists

Answer 9

1. Glycine
2. beta-alanine
3. Taurine

Question 10

Glycine receptor antagonist

Answer 10

Strychnine

Question 11

Where does binding occur at glycine receptor?

Answer 11

N terminus of alpha subunit

Question 12

Mutations of the alpha subunit of glycine receptor leads to?

Answer 12

Hyperekplexia

Question 13

Cytosolic region of glycine receptor is?

Answer 13

Beta subunit (for targeting and tethering)

Question 14

Beta cytostolic region of glycine receptor interact with?

Answer 14

Gephyrin

Question 15

What subunit lines the pore of glycine receptor?

Answer 15

M2

Question 16

Glycine receptor has selective conductance for what ion?

Answer 16

Cl-

Multiple conductance states

Question 17

What modulates activity of glycine receptor?

Answer 17

Phosphorylation (PKA, PKC, tyrosine kinase)