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Physiology Exam 5 > GABA(A) Receptor > Flashcards

GABA(A) Receptor Flashcards

1
Q

GABA stands for?

A

Gamma amino butyric acid

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2
Q

GABA(A) receptor is a?

A

Heteropentamer

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3
Q

Most common GABA(A) receptor type

A

2alpha, 2beta, gamma

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4
Q

GABA(A) receptor agonists which compete for the same site

A
  1. GABA
  2. Baclofen
  3. Muscimol
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5
Q

GABA(A) receptor allosteric agonists

A
  1. Benzodiazepines
  2. Ethanol
  3. Barbiturates
  4. Avermectins
  5. Volatile anesthetics
  6. Some steroids
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6
Q

GABA(A) receptor antagonists

A
  1. Bicuculline

2. Some steroids

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7
Q

Mutations of the GABA(A) receptor are associated with?

A

Epilepsy and seizures

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8
Q

GABA(A) receptor inverse agonist

A

DMCM

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9
Q

What is an inverse agonist?

A

Binds to same receptor as agonist but produces opposite response

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10
Q

Gephryin is linked to?

A
  1. Tubules
  2. Profilin (actin)
  3. Collybistin
  4. Neuroglin 2
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11
Q

Collybistin is?

A

GTP exchange protein

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12
Q

Neuroligin 2 also interacts with?

A

Presynaptic neurexins

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13
Q

2 conditions associated with hyperekplexia

A
  1. Acoustic startle

2. Stiff baby

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14
Q

GABA and Glycine uptake/reuptake mechanisms are present in?

A
  1. Presynaptic nn.

2. Associated neuroglia

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15
Q

Glycine reuptake into presynaptic cell is regulated by what receptor?

A

GlyT2

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16
Q

Glycine reuptake into glial cell is regulated by what receptor?

A

GlyT1

17
Q

GABA reuptake into glial cell is regulated by what receptor?

A

GAT3

18
Q

How does glial cell recycle GABA?

A

Converts to gluamine

19
Q

How does presynaptic neuron take up recycled glutamine?

A

SNAT1 or SNAT2

20
Q

GABA reuptake into presynaptic cell is regulated by what?

A

GAT-1

21
Q

Glycine has what efect on post-synaptic cell?

A

Inhibits

22
Q

What hapens when glycine or GABA causes Cl- channels to open?

A

Hyperpolarizes cell

23
Q

What type of inhibition can be overcome by increasing ligand concentration?

A

Competitive inhibition

24
Q

GABA and glycine have what ultimate fate?

A

Reuptake

25
Q

ACh has what ultimate fate?

A

Breakdown

26
Q

Serotonin has what ultimate fate?

A

Breakdown or reuptake

27
Q

ACh is broken down by?

A

Cholinesterase

28
Q

Serotonin is broken down by?

A

Monoamine oxidase

29
Q

Serotonin reuptake is modulated by what receptor?

A

SERTs

30
Q

4 methods of response termination

A
  1. Dissociation
  2. Desensitization
  3. Down regulation
  4. Transmiter removal
31
Q

3 methods of transmitter removal

A
  1. Breakdown/metabolism
  2. Diffusion from cleft
  3. Reuptake

Physiology Exam 5 (11 decks)

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