GABA(A) Receptor

Question 1

GABA stands for?

Answer 1

Gamma amino butyric acid

Question 2

GABA(A) receptor is a?

Answer 2

Heteropentamer

Question 3

Most common GABA(A) receptor type

Answer 3

2alpha, 2beta, gamma

Question 4

GABA(A) receptor agonists which compete for the same site

Answer 4

1. GABA
2. Baclofen
3. Muscimol

Question 5

GABA(A) receptor allosteric agonists

Answer 5

1. Benzodiazepines
2. Ethanol
3. Barbiturates
4. Avermectins
5. Volatile anesthetics
6. Some steroids

Question 6

GABA(A) receptor antagonists

Answer 6

1. Bicuculline

2. Some steroids

Question 7

Mutations of the GABA(A) receptor are associated with?

Answer 7

Epilepsy and seizures

Question 8

GABA(A) receptor inverse agonist

Answer 8

DMCM

Question 9

What is an inverse agonist?

Answer 9

Binds to same receptor as agonist but produces opposite response

Question 10

Gephryin is linked to?

Answer 10

1. Tubules
2. Profilin (actin)
3. Collybistin
4. Neuroglin 2

Question 11

Collybistin is?

Answer 11

GTP exchange protein

Question 12

Neuroligin 2 also interacts with?

Answer 12

Presynaptic neurexins

Question 13

2 conditions associated with hyperekplexia

Answer 13

1. Acoustic startle

2. Stiff baby

Question 14

GABA and Glycine uptake/reuptake mechanisms are present in?

Answer 14

1. Presynaptic nn.

2. Associated neuroglia

Question 15

Glycine reuptake into presynaptic cell is regulated by what receptor?

Answer 15

GlyT2

Question 16

Glycine reuptake into glial cell is regulated by what receptor?

Answer 16

GlyT1

Question 17

GABA reuptake into glial cell is regulated by what receptor?

Answer 17

GAT3

Question 18

How does glial cell recycle GABA?

Answer 18

Converts to gluamine

Question 19

How does presynaptic neuron take up recycled glutamine?

Answer 19

SNAT1 or SNAT2

Question 20

GABA reuptake into presynaptic cell is regulated by what?

Answer 20

GAT-1

Question 21

Glycine has what efect on post-synaptic cell?

Answer 21

Inhibits

Question 22

What hapens when glycine or GABA causes Cl- channels to open?

Answer 22

Hyperpolarizes cell

Question 23

What type of inhibition can be overcome by increasing ligand concentration?

Answer 23

Competitive inhibition

Question 24

GABA and glycine have what ultimate fate?

Answer 24

Reuptake

Question 25

ACh has what ultimate fate?

Answer 25

Breakdown

Question 26

Serotonin has what ultimate fate?

Answer 26

Breakdown or reuptake

Question 27

ACh is broken down by?

Answer 27

Cholinesterase

Question 28

Serotonin is broken down by?

Answer 28

Monoamine oxidase

Question 29

Serotonin reuptake is modulated by what receptor?

Answer 29

SERTs

Question 30

4 methods of response termination

Answer 30

1. Dissociation
2. Desensitization
3. Down regulation
4. Transmiter removal

Question 31

3 methods of transmitter removal

Answer 31

1. Breakdown/metabolism
2. Diffusion from cleft
3. Reuptake