Neurotransmitter Receptors & Pharmacology

Question 1

3 sites of cholinergic receptors

Answer 1

1. Autonomic ganglionic
2. Parasympathetic postganglionic
3. Neuromuscular junction

Question 2

Cholinergic receptor at autonomic ganglionic

Answer 2

Nicotinic N(G)

Question 3

Parasympathetic postganglionic cholinergic receptor

Answer 3

Muscarinic M(2)

Question 4

Cholinergic receptor at neuromuscular junction

Answer 4

Nicotinic N(M)

Question 5

What does belladona target?

Answer 5

Parasympathetic postganglionic muscarinic M(2)

Question 6

Examples of nicotinic cholinergic ligands

Answer 6

1. ACh
2. Hexamethonium
3. Decamethonium
4. Succinylcholine

Question 7

Hexamethonium is?

Answer 7

Ganlionic antagonist (N(G))→ non-depolarizing blocker

Question 8

Decamethonium is?

Answer 8

Neuromuscular (N(M)) → depolarizing blocker

Question 9

How does agonist binding activate receptor?

Answer 9

Induces conformational shift (picture lock and key)

Question 10

2 major types of metabotropic Nt receptors

Answer 10

1. G-protein linked

2. Tyrosine kinase linked

Question 11

Examples of G-protein linked receptors

Answer 11

1. Beta-adrenergic
2. M(2) muscarinic
3. alpha(1)-adrenergic
4. H(1) histaminergic

Question 12

Receptor associated with G(s)/cAMP pathway

Answer 12

beta-adrenergic

Question 13

Receptor associated with G(i)/cAMP pathway

Answer 13

M(2) muscarinic

Question 14

Receptor associated with G(q)/IP(3)/DAG pathway

Answer 14

alpha(1)-adrenergic

Question 15

Receptor associated with G(q)/NO/cGMP pathway

Answer 15

H(1) histaminergic

Question 16

2 examples of tyrosine kinase linked receptors

Answer 16

Dopamine and NMDA receptor modulation

Question 17

How do non-covalent bonds relate to the “lock and key model”?

Answer 17

Agonists will occupy all important non-covalent bond sites to induce change

Question 18

Beta(2)-adrenergic receptors are found on what organ?

Answer 18

Bronchi

Question 19

Beta(1)-adrenergic receptors are found on what organ?

Answer 19

Heart

Question 20

Atenolol

Answer 20

Blocks beta(1) → selective antagonist