Ligand Gated Ion Channels I

Question 1

EPSP stands for?

Answer 1

Excitatory postsynaptic potential

Question 2

IPSP stands for?

Answer 2

Inhibitory postsnyaptic potential

Question 3

Depolarization is associated with?

Answer 3

Activation of selected ionotropic receptors (EPSP)

Question 4

When you hear conductances, you should think of?

Answer 4

Channels

Question 5

4 neurotransmitter classes that modulate membrane conductances

Answer 5

1. Cholinergis
2. Purines
3. Biogenic amins
4. AAs

Question 6

Acetylcholine is what type of neurotransmitter?

Answer 6

Cholinergic

Question 7

3 neurotransmitter classes that are associated with cation channels

Answer 7

1. Cholinergic
2. Purines
3. Biogenic amines

Question 8

ATP is what type of neurotransmitter?

Answer 8

Purine

Question 9

Serotonin is what type of neurotransmitter?

Answer 9

Biogeni amine

Question 10

3 types of AA neurotransmitter

Answer 10

1. Glutamate
2. Glycine
3. GABA

Question 11

Glutamate associates with cation/anion channel

Answer 11

Cation

Question 12

Glycine associates with cation/anion channel

Answer 12

Anion → Cl-

Question 13

GABA associates with cation/anion channel

Answer 13

Anion → Cl-

Question 14

Cationic channels are EPSP/IPSP

Answer 14

EPSP

Question 15

Anionic channels are EPSP/IPSP

Answer 15

IPSP

Question 16

2 types of purine receptors

Answer 16

1. P2X receptor

2. Nonselective cation channels

Question 17

Purine receptor subunit intracellular structures

Answer 17

Cytosolic N and C termini

Question 18

Purine receptor subunit extracellular structure

Answer 18

Extracellular loop including ligand binding site

Question 19

Purine receptors are widely distributed in?

Answer 19

1. CNS
2. PNS
3. Neuroglia

Question 20

Purine receptors may have a role in?

Answer 20

1. Mechanosensation

2. Neuropathic pain

Question 21

ACh/GABA/Gly receptor subunit structure

Answer 21

4 membrane spanning domains

Question 22

ACh/GABA/Gly channel is made of ___ subunits

Answer 22

5 subunits

Question 23

ACh/GABA/Gly receptor extracellular structures

Answer 23

N & C termini

Question 24

Primary inhibitory Nt in brain and spinal cord is?

Answer 24

GABA

Question 25

Site of action for alcohol, barbiturates and benzodiazepines

Answer 25

GABA(A)

Question 26

Inhibitory Nt in spinal cord which affect antagonistic mm.

Answer 26

Glycine

Question 27

Glutamate receptor subunit structure

Answer 27

3 transmembrane segments and P loop

Question 28

Glutamate channel is made of ___ subunits

Answer 28

4 or 5

Question 29

All type of glutamate receptors are permeant to what ions?

Answer 29

Na+ and K+

Question 30

Glutamate receptor subtypes

Answer 30

1. AMPA
2. Kainate
3. NMDA

Question 31

NMDA glutamate receptors are permeant to what ion other than Na+ and K+?

Answer 31

Ca2+

Question 32

What receptor is the target for hallucinogenic drugs?

Answer 32

NMDA glutamate receptor

Question 33

Extracellular subunit motif usually has what function?

Answer 33

Ligand binding

Question 34

Nicotinic ACh receptor is excitatory/inhibitory

Answer 34

Excitatory

Question 35

Glycine receptor is excitatory/inhibitory

Answer 35

Inhibitory

Question 36

GABA(A) receptor is excitatory/inhibitory

Answer 36

Inhibitory

Question 37

Transmembrane subunit motif usually has what function?

Answer 37

Ion selectivity

Question 38

Intracellular subunit motif usually has what function?

Answer 38

Targeting and anchoring

Question 39

Extracellular N and C termini for nACh/Gly/GABA(A) receptor

Answer 39

1. Consensus sites for glycosylation
2. Have 2 cystine residues separated by 13 AAs which form a disulfide bond
3. Responsible for ligand binding

Question 40

M2 segments of nACh/Gly?GABA(A) contributed by each subunit forms?

Answer 40

Aqueous pore or ion channel → responsible for ion selectivity