nAchR Flashcards
1
Q
nACh receptor is located at?
A
Neuromuscular junction
2
Q
nACh receptor is a?
A
Heteropentamer
3
Q
ACh binds to what subunit?
A
alpha
4
Q
nAChR agonists
A
- Nicotine
- Carbamylcholine
- Succinylcholine
- Levamisole
- Pyrantel target helminth homolog
5
Q
nAchR antagonists
A
- Trimethaphan
- alpha Bungarotoxin
- Curare
6
Q
Trimethaphan is a?
A
Ganglionic block
7
Q
What subunit lines pore of nAchR?
A
M2 → determines ion selectivity
8
Q
nAchR is nonselective for?
A
Monovalent cations (Na+ and K+)
9
Q
What subunit of nAchR determines ligand affinity?
A
alpha → one binding site per alpha subunit
10
Q
What subunit of nAchR determines localization?
A
beta
11
Q
All forms of nAchR contain how many alpha subunits?
A
2
12
Q
When nAchR causes cation channels to open, what happens?
A
Depolarization
