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Neurochemistry > Serotonin > Flashcards

Serotonin Flashcards

1
Q

Source

A

Tryptophan - 5-hydroxy l-tryptophan - serotonin

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2
Q

Rate limiting step

A

Availability of tryptophan

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3
Q

Synthetic enzymes

A

Tryptophan hydroxylase

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4
Q

Breakdown enzymes

A

MAO (preferentially MAO-A)

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5
Q

Breakdown product

A

5-hydroxyindoleacetic acid (5-HIAA)

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6
Q

Reuptake

A

Serotonin reuptake channel (tricyclics, SSRIs inhibit)

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7
Q

Function

A

Mood
Perception of pain
Feeding
Sleep-wake cycle
Motor activity

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8
Q

Receptors

A

14 - all except 5HT3 are G protein coupled receptors

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9
Q

Disorders

A

Low - increased depression, aggression, suicide and impulsivity

Role in psychosis

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10
Q

Receptors

A

1A - antidepressant (ag), anxiolytic (part ag)
1B - aggression
1D - antimigraine (ant)
2A - antipsychotic (ant), hallucinogens (ag/ part ag), working memory, platalets, muscles
2B - cardiac valvular fibrosis
2C - anxiogenic, anorexic (ag)
3 - antiemetic (ant)
6 - antipsychotic / antidepressant action (ant)
7 - circadian rhythm

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Neurochemistry (8 decks)

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