Others

Question 1

Glycine

Answer 1

Primary inhibitory neuotransmitter in spinal cord

‘Mandatory adjunctive neurotransmitter’ for glutamate receptors (non-strychnine-sensitive glycine receptor)

Strychnine-sensitive glycine receptors are inhibitory receptors in the spinal cord

Facilitating transmission can help reduce -ve symptoms (bitopertin)

Question 2

Endocannabinoids

Answer 2

Two endogenous substances - anandamide (weak ligand), arachnidonylglycerol (strong ligand) - formed from arachidonic acid and ethanolamine

CB1 (central), CB2 (peripheral) - both bind tetrahydrocannabinol (THC)

Anandamide lowers intraocular pressure, decreases activity level and relieves pain