Dopamine Flashcards
1
Q
Source
A
Tyrosine - L-dopa - dopamine
2
Q
Rate limiting step
A
Tyrosine hydroxylase
3
Q
Breakdown enzymes
A
MAO and COMT
MAOB more selectively metabolises dopamine than MAOA
4
Q
Breakdown product
A
Homovallinic acid
5
Q
Reuptake
A
Dopamine transporter - cocaine inhibits
6
Q
Function
A
Motivation
Novelty seeking
Reward circuitry
Arousal
Motor movement in basal ganglia
7
Q
Receptors
A
All G protein coupled / metabotropic
D1 (postsynaptic) and D5 (limbic) - increase adenylate cyclase
D2, D3, D4 - decrease adenylate cyclase. D4 primarily in frontal cortex ans clozapine has a high affinity