Dopamine Flashcards

1
Q

Source

A

Tyrosine - L-dopa - dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Rate limiting step

A

Tyrosine hydroxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Breakdown enzymes

A

MAO and COMT

MAOB more selectively metabolises dopamine than MAOA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Breakdown product

A

Homovallinic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Reuptake

A

Dopamine transporter - cocaine inhibits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Function

A

Motivation
Novelty seeking
Reward circuitry
Arousal
Motor movement in basal ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Receptors

A

All G protein coupled / metabotropic

D1 (postsynaptic) and D5 (limbic) - increase adenylate cyclase

D2, D3, D4 - decrease adenylate cyclase. D4 primarily in frontal cortex ans clozapine has a high affinity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly