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Neurochemistry > Noradrenaline > Flashcards

Noradrenaline Flashcards

1
Q

Source

A

Tyrosine - l-dopa - dopamine - norepinephrine - epinephrine

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2
Q

Rate limiting step

A

Tyrosine hydroxylase

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3
Q

Synthetic enzymes

A

Dopamine-b-hydroxylase - modulated norepinephrine production

Phenylethanolamine-N-methyltransferase modulates conversion of NEN to epinephrine

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4
Q

Breakdown enzymes

A

COMT and MAO (especially MAOA)

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5
Q

Breakdown product

A

3-methoxy-4-hydroxyphenylglycol (MHPG) + VMA

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6
Q

Reuptake

A

Noradrenaline reuptake channels (tricyclics, reboxetine inhibit this)

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7
Q

Function

A

Arousal
Anxiety
Mood regulation
Autonomic mediation

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8
Q

Receptors

A

Alpha1 - phospholipase C coupled, mostly postsynaptic

Alpha2 - Gi coupled, mostly presynaptic

Alpha2 - Gs coupled, mostly presynaptic

B - Gs coupled, locus cerukeus (B1 norepinephrine, B2 epinephrine)

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9
Q

Disorders

A

Low in depression
Abnormal in panic / anxiety disorders

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Neurochemistry (8 decks)

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