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Neurochemistry > Acetylcholine > Flashcards

Acetylcholine Flashcards

1
Q

Source

A

Choline + acetyl-coenzyme A

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2
Q

Rate limiting step

A

Availability of choline

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3
Q

Synthetic enzymes

A

Choline acetyltransferase

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4
Q

Breakdown enzymes

A

Acetylcholinesterase - rapid metabolism

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5
Q

Breakdown product

A

Choline

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6
Q

Reuptake

A

No reuptake
Degraded choline is re uptaken and recycled

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7
Q

Function

A

Modulate arousal
Learning
Memory
REM sleep
Pain perception
Thirst
Parasympathetic mediation

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8
Q

Receptors (cholinergic)

A

Muscarinic - G-protein coupled (M1-M5)

Nicotinic - ion channels (excitation of neurone)

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9
Q

Disorders

A

Reduced cholinergic function in AD

Dopamine balance in PD

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Neurochemistry (8 decks)

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