Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunohematology > Serology final > Flashcards

Serology final Flashcards

1
Q

What does FTA-ABS stand for?

A

fluorescent treponema antibody absorption test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the FTA-ABS?

A

test of choice to confirm reactive VDRL or RPR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the causative agent of infectious mononucleosis?

A

Epstein-Barr virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the causative agent of syphilis?

A

Treponema pallidum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the first immunoglobulin produced first after exposure to an antigen?

A

IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the immunoglobulin found in the greatest concentration?

A

IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the immunoglobulin appearing in the greatest concentration to a second antigen exposure?

A

IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the immunoglobulin associated with allergic reactions?

A

IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is an animistic reaction?

A

Second and subsequent exposure to antigen, memory response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is prozone?

A

excess antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is postzone?

A

excess antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is flocculation?

A

very specific type of precipitation that occurs over a narrow range of antigen concentration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the most widely used flocculation test?

A

RPR and VDRL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is an example of a cross-reaction?

A

Ouchterlony double diffusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the Fc fragment?

A

site of complement attachment/activation, directs biological activity of the antibody molecule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What does passive immunity result from?

A

injection of antibodies derived from another individual, antibodies acquired in utero from maternal circulation, antibodies acquired postpartum from mother’s milk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What does active immunity result from?

A

induced by exposure to an infectious agent itself, natural infection or vaccination

18
Q

What is adoptive immunity?

A

produced by the transfer of antigen sensitive lymphocytes from an actively immunized donor to a non immune recipient

19
Q

What is the Fab fragment?

A

site of antigen biding composed of 1 light chain and half of a heavy chain

20
Q

What is the constant region?

A

associated with different biological properties which vary between Ig classes

21
Q

What is the variable region?

A

provides specificity for antigen binding

22
Q

What is the sequence of the classical complement pathway?

A

C1 C4 C2 C3 C5 C6 C7 C8 C9

23
Q

What is the correct order of appearance of the specific markers for hepatitis B infection

A

HBsAg, HBeAg, anti-HBc Igm, anti-HBe, anti-HBs

24
Q

What is the test most widely used to detect HIV antibody?

A

CD4 T-cell enumeration, flow cytometry

25
Q

How long on average does it take for an individual to develop HIV antibodies after exposure to the HIV virus?

A

6 weeks or 10 years

26
Q

What is the RAST used for?

A

identifying IgE antibodies

27
Q

Multiple myeloma most commonly involves which immunoglobulin class?

A

IgG

28
Q

What is the main barrier against foreign particle invasion into the body?

A

skin

29
Q

Describe HBsAg

A

spears 2-12 weeks after exposure, becomes undetectable at 6-12 weeks in acute, remains elevated in chronic

30
Q

Describe HBeAg

A

appears shortly after HBsAg, may stay elevated in chronic

31
Q

Describe IgM anti-HBc

A

indicates current or recent acute infection, appears weeks after HBsAg and stays up to 6 months

32
Q

Describe anti-HBe

A

appears shortly before HBeAg disappears, indicates patient is recovering from acute

33
Q

Describe anti-HBs

A

appears during record of acute infection

34
Q

Principle of Davidson test

A

determination of the anti-sheep antibodies after absorption with guinea pig kidney

35
Q

Describe positive Davidson test

A

complete removal of anti-sheep Ab by guinea pig kidney and/or beef RBCs

36
Q

Describe heterophile antibody

A

Ab that reacts with Ag that is unrelated to the Ag that caused its production; separated into Forssman and Non-Forssman types

37
Q

Describe Forssman Ab

A

must be removed from patient serum before serologic testing because it causes questionable results

38
Q

What is the Paul-Bunnell presumptive test?

A

based on the agglutination of 2% sheep RBCs by all heterophile Ab in patient serum

39
Q

What is Paul-Bunnell positive for?

A

IM Ab, Forssman Ab, and serum sickness; IM confirmed by Davidson test

40
Q

What is the Davidson differential test?

A

determines anti-sheep Ab after absorption with Guinea pig kidney and/or beef RBCs

41
Q

What is Davidson differential test positive for?

A

indicated by complete removal of anti-sheep agglutinins by guinea pig kidney and/or beef RBCs

Immunohematology (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions