SEPSIS Syndrome

Question 1

qSOFA

Answer 1

(HAT)

• Systolic BP < 100 mm Hg
• Altered mental status
• RR > 22

Grading: 1 pt/criteria; 2 or greater is bad outcome

Question 2

SOFA

Answer 2

1. Respiratory
2. Coagulation
3. Liver
4. CV (BP + meds)
5. CNS/GCS
6. Renal

Question 3

SIRS

Answer 3

Noninfectious systemic dysregulated inflammation

Criteria-Two or more of the following: 
Temperature of >38°C or <36°C
Heart Rate of >90 bpm
Respiratory rate of > 20 bpm
WBC count  cells/uL> 12,000 cells/uLor <4,000 cells/uLor >10% bands

Question 4

Substances Increasing Vascular Permeability/Vasodilation:

Answer 4

Nitric oxide (NO)
Platelet Activating factor (PAF)
Prostaglandin E (PGE)
Bradykinin
Serotonin
Histamine
Ca2+

Question 5

Management of SEPSIS

Answer 5

• ABCs
• Fluids
• Rapid Abx
• Blood culture X2 before abx
• lactate

Question 6

Possible MRSA Abx Tx

Answer 6

Vancomycin w/
1. 3/4th gen Cephalosporin
OR
2. B-lactam w/ inhibitor
OR 
3. Carbapenam

Question 7

Possible Pseudomonas Abx Tx

Answer 7

Vancomycin w/ 2 of the following:

• Anti-Ps Ceph
• Anti-Ps Carb
• Anti-Ps B-Lac/inh
• Cipro
• Aminoglycoside
• Monobactam