Segundos mensajeros Flashcards

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1
Q

QuƩ degrada al AMPc?q

A

La AMPc fosfodiesterasa

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2
Q

QuƩ hace el PKA?

A

Fosforila el CREB

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3
Q

QuƩ hace CREB

A

Regula la respuesta del AMPc

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4
Q

El sistema de fosfolĆ­pidos cĆ³mo se activa?

A

Receptores acoplados a proteĆ­nas G(q) (PLC-B)

Receptores tirosin-cinasa (PLC - y)
PLC = fosfolipasa

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5
Q

Proceso del Fosfatidilinositol de proteĆ­nas G

A

el PIP2 es fosforilado por la fosfolipasa C = inositol -1,4,5,-trifosfato (IP3) y diacilglicerol (DAG)

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6
Q

QuƩ hace IP3?

A

Abre canales de Ca+2

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7
Q

QuƩ hace el DAG?

A

Avtiva a la proteĆ­na PKC para secreciĆ³n celular y expresiĆ³n de genes

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8
Q

Proceso de fosfatidilinositol del receptores tirosin cinasa

A

Fosfatidilinositol 4,5 bifosfato es fosforilado por el fosfatidilinositol 3 cinasa = fosfatidil inositol 3,4,5 - trifosfato (PIP3)

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9
Q

QuƩ hace el PIP3?

A

Activa el PKB o Akt
Akt1: inhibe apoptosis
Akt2: seƱalizaciĆ³n de insulina
Akt3: Cerebro

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10
Q

Calcio como segundo mensajero

A

Calmodulina se une al calcio y activan a muchas cinasas
CREB

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11
Q

Reclutamiento de proteĆ­nas

A

Receptores tirosin-cinasa y receptores acoplados a proteĆ­nas G
-Ras: Fosforila a Raf
- Raf: fosforila MAPK cinasas
- MAPK fosforilan cinasas serina/ treonina

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