Sedative/Hypnotic

Question 1

Sedative-Hypnotic Drugs

Answer 1

Drugs that depress central nervous system (CNS) function

Primarily used to treat anxiety and insomnia

Question 2

pharmacologic effects of benzos

Answer 2

CNS: reduce anxiety & promote sleep
Cardio: oral (no effects) IV (hypotension & cardiac arrest)
Respiratory: weak resp. depressant

Question 3

therapeutic use of benzos

Answer 3

anxiety, insomnia, seizure disorders, muscle spasms

Question 4

adverse effects

Answer 4

CNS depression, temp memory impairment, res. depression

Question 5

black box warning for benzos

Answer 5

using with opioids may result in profound sedation = death

Question 6

3 main drugs

Answer 6

diazepam
lorazepam
alprazolam

Question 7

toxicity treatment for benzos

Answer 7

flumazenil = will reverse the sedative effects

Question 8

barbiturates

Answer 8

Cause tolerance and dependence
High abuse potential
Used less often than in the past b/c they have been replaced by safer drugs

Question 9

mech of action of barbiturates

Answer 9

binds to GABA receptors

Question 10

Barbiturates interactions

Answer 10

CNS depressants

Interactions that result from the induction of drug-metabolizing enzymes

Question 11

Barbiturates adverse effects

Answer 11

Respiratory depression
Suicide
Abuse

Question 12

Acute toxicity of barbiturates

Answer 12

Respiratory depression
Coma
Pinpoint pupils

Activated charcoal

Question 13

Drugs Used for Treatment

of Insomnia

Answer 13

Benzodiazepines - drugs of first choice