antidepressants Flashcards

1
Q

when is initial response seen?

A

may be up to 12 wks

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2
Q

SSRIs

A
  • Selective Serotonin Reuptake Inhibitors
  • Most commonly prescribed
  • Fluoxetine
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3
Q

Fluoxetine

A
  • Produces CNS excitation

- Side effects: Serotonin syndrome, sexual dysfunction, insomnia, drowsiness

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4
Q

Serotonin syndrome

A
  • begins 2-72 hrs after treatment

- altered mental status including agitation, confusion, hallucination

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5
Q

Drug interactions w/ Fluoxetine

A

anti platelet drugs and anti coagulants can increase risk of GI tract (Aspirin & Warfarin)

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6
Q

nursing actions for SSRIs

A
  • should be discontinued gradually

- effects 1-4 weeks

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7
Q

SNRIs

A

Venlafazine & Duloxetine

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8
Q

Duloxetine (SNRI)

A

adverse effects: nausea, dry mouth, orthostatic hypotension

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9
Q

TCA

A

adverse effects: orthostatic hypotension, cardiac toxicity, anticholinergic effects, screened w/ EKG

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10
Q

drug interactions w/ TCA

A
  • TCA and MAOIs lead to severe hypertension
  • TCA and CNS depressants
  • no alc
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11
Q

TCA toxicity

A

dysrhythmias, tachycardia= primarily from cadiotoxic actions

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12
Q

treatment for TCA toxicity?

A

activated charcoal

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13
Q

when should TCA be taken?

A

at night to avoid sedation

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14
Q

MAOIs

A
  • 2nd or 3rd choice for antidepressants

- TYRAMINE

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15
Q

prototype drug for MAOIs

A

Phenelzine

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16
Q

adverse effects of MAOIs

A

CNS Stim, orthostatic hypotension, hypertensive crisis

17
Q

atypical antidep

A

Bupropion

doesn’t cause any of the side effects SSRI’s do

18
Q

drug interactions of atypical

A

MAOIs can increase risk of bupropion toxicity