Antipsychotics Flashcards
antipsychotics
used in various psychotic disorders: Schizophrenia, delusional disorders, bipolar disorders, depressive psychoses
First Generation Antipsychotics
extra-pyrimdal symptoms
drug: Haloperidol
mainly for schizophrenia
Second Gen Antipsychotics
metabolic side effects
aka atypical
drug: Clozapine
what are metabolic effects of second generation?
- weight gain
- diabetes
- dyslipidemia
Parkinsonism
Bradykinesia, mask-like facies, drooling, tremor, rigidity, shuffling gait, cogwheeling, and stooped posture
Akathisia
Pacing and squirming brought on by an uncontrollable need to be in motion
Tardive dyskinesia
Involuntary movements of the tongue and face; lip-smacking movements; tongue flicks out in a “fly-catching” motion; slow, worm-like movement of the tongue; and involuntary movements of the limbs, toes, fingers, and trunk.
Agranulocytosis
severely compromises the ability to fight infection, a white blood cell (WBC) count should be done whenever signs of infection
high potency agents
cause more EPS
but less sedation, orthostatic hypoten, and anticholinergic effects
preferred initial therapy i.e. Haloperidol
low potency agents
can’t see, pee, poop, spit
low potency agents
can’t see, pee, poop, spit
Clozapine
SGA
adverse: agranulocytosis, seizures, metabolic side effects
Depot antipsychotics
Long-acting, injectable formulations used for the long-term maintenance therapy of schizophrenia
No evidence that depot preparations pose an increased risk of side effects
Three major objectives of Schizophrenia Drug Therapy
Suppression of acute episodes
Prevention of acute exacerbations
Maintenance of the highest possible level of functioning
routes of schizo drug
oral IM inhaled
