Section 3: Hematopoiesis Flashcards
What does cythemia mean?
Specific to blood cells, usually increased number
Most blood cell production occurs in which organ at birth?
Bone marrow
In which body parts is the bone marrow active in adults?
Pelvic, spine, ribs, skull, shoulders, top of femur
Distinguish between yellow and red marrow
Yellow = mostly fat
Red marrow = mostly developing blood cell lines
Normal adult bone marrow tissue displays what percent tissue and fat?
50% each
Function of spleen?
- Macrophages
- IgM synthesis
- Storage of platelets
- Site of extramedullary (outside BM) hematopoiesis
Function of liver?
- synthesize proteins/coagulation factors
- store vitamins and minerals
- conjugate and transport bilirubin
- site of extramedullary
Diseases in liver?
- hemolytic anemias/RBC dysplasia
- porphyrias (enzymatic deficiency)
- lipid storage diseases
What is porphyrias?
Enzymatic deficiency that results in accumulation of intermediate products of heme production
Differences between lymph and blood composition?
Lymph has lower protein content and no RBCs
Lymph node function?
Proliferation of lymphocytes
Processing of specific Ig
Filter junk and bacteria
Pathophysiology of lymph nodes?
Filtration function makes them susceptible to infection and malignant cells
Thymus function? What cells does it hold?
T cell maturation. Holds T. cells, B cells, eosinophils, neutrophils, and myeloid cells
Non-development of thymus during gestation and adulthood differences?
Gestation: lack of T cell formation -> impaired immune response
Adulthood: maintain T cell pool for life
Two types of stem cells?
- Pluripotential SC (noncommitted)
- Lineage specific precursor (committed/multipotential)
