Section 10: Megakaryocytopoiesis PLT Series

Question 1

Define -petechia

Answer 1

Pin head sized sites of bleeding under the skin due to a decreased/low PLT count

Question 2

Define -thrombocytopenia

Answer 2

Due to decreased production or increased consumption (PLT destruction)

Question 3

Define -purpura in regards to platelet numbers

Answer 3

references a decrease number of PLTs caused by a blood disorder, looks similar to petechia but is slightly larger under the skin

Question 4

Define -thrombocytosis

Primary and Secondary

Answer 4

Primary - due to malignant proliferation
Secondary due to reactive response - trauma, blood loss, tiss damage, inflammation and exercise

Question 5

Define -endomitosis

Answer 5

during proliferation, the promegakaryoblast undergoes endomitosis which results in the giant cell, the megakaryocyte

Question 6

State the function of platelets

Answer 6

primary function of platelets is to prevent and stop bleeding with the use of fibrinogen

Question 7

list the stages of megakaryocytopoiesis in order of maturation.

Answer 7

Megakaryoblast
Promegakaryocyte
Megakaryocyte
Thrombocyte

Question 8

list the causes of thrombocytosis and thrombocytopenia

Answer 8

Thrombocytosis- two causes (Primary and Secondary)
Thrombocytopenia - BM disorders, leukemias, bone marrow infection …etc

Question 9

Be able to differentiate the following cells on a wright stained smear: Megakaryoblast, promegakaryocyte, megakaryocyte thrombocyte

Answer 9

Images later :)

Question 10

Discuss how clumped platelets should be handled when found on an automated CBC report and / or peripheral blood smear

Question 11

Identify the following Cell:

Answer 11

Megakaryoblast

Question 12

Identify the Following Cell:

Answer 12

Promegakaryocyte

Question 13

Identify the Following Cell:

Answer 13

Megakaryocyte

Question 14

Identify the Following Cell:

Answer 14

Megakaryocyte without PLTS

Question 15

Identify the Following Cell:

Answer 15

Megakaryocyte with PLTS