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Bio 2370 No. 1 > Secretion system- protein translocation > Flashcards

Secretion system- protein translocation Flashcards

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1
Q

What gram bacteria used the sec system

A

gram +ive and -ive

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2
Q

What is the purpose of sec system

A

insert protein in PM or transfer unfolded protein across PM

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3
Q

In which direction are proteins synthesized

A

in the N to C direction

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4
Q

describe the N and C terminus of proteins

A

has an unbound amino group and unbound carboxyl group respectively

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5
Q

What does it mean when an amino group is unbound

A

not convalently linked to the next one

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6
Q

What are other names for the signal peptide

A

leader peptide or signal sequence

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7
Q

What are proteins w/a signal peptide called

A

preproteins

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8
Q

what is the hydrophobicity of the central part of the signal peptide

A

hydrophobic

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9
Q

Describe the signal peptide

A

proteins translocated by system are synthesized w/25 aa long peptide on N terminal

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10
Q

what is SecB

A

cytoplasmic chaperone (helper)

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11
Q

what is SecYEG

A

3 proteins that form an integral PM protein chain or translocase

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12
Q

What is secA

A

bound to inner surface of SecYEG, an ATPase meaning it hydrolyzes ATP

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13
Q

Where is the signal peptidase located

A

outer surface of PM

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14
Q

What is the fn of signal peptidase

A

removes the signal peptide from preprotein

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15
Q

How does secB, the chaperone protein have time to bind

A

as preprotein is being synthesized signal peptide slows folding of preprotein

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16
Q

What happeds after secB binds to preprotein

A

inhibits further folding and delivers preprotein to secA, secB is released

17
Q

How is the signal peptide inserted into the lipid bilayer

A

N terminius of signal peptide binds to surface of PM and hydrophobic region is inserted into bilayer. remainder of preprotein passes through a pore in SecYEG, at this point most is still in cytoplasm

18
Q

how is the preprotein released

A

secA hydrolyzes ATP

19
Q

how is the rest of the protein translocased to the periplasm

A

secYEG translocase uses PMF as nrg

20
Q

How is the signal peptide and protein separated

A

signal peptidase cuts signal peptidase, protein release into periplasm and folds into its tertiary structure

Bio 2370 No. 1 (16 decks)

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