Secretion liver and pancreas Flashcards
1
Q
CCK-PZ- Cholecystokinin
A
From I cells stimulates pancreatic secretion and gall bladder emptying broken down by trypsin if lack of food stimulated by lipids and peptides --> sphincter of Oddi to relax
2
Q
Secretin
A
S cells (duodenum) stimulates HCO3- secretion and has trophic effects on pancreas
3
Q
Hepatocytes
A
secrete bile components into ducts
where HCO3-, salt and water are added
stimulated by secretin and involves CFTR channels
4
Q
Gastrin
A
mainly active in antrum>duodenum>jejunum
5
Q
CCK
A
duodenum>jejunum>ileum
6
Q
GIP
A
duodenum=jejunum} drives insulin secretion
decreases secretion stomach acid
7
Q
Bile
A
cations exceed anions –> bile acids -ve charge
8
Q
Cholesterol –> primary bile acid:
A
1) cholesterol –> cholic acid–> secondary deoxycholic acid –> bile salts: glycine (carboxyl group)
2) cholesterol –> chenodeoxycholic acid –> lithocoluc acid –> taurine (sulfate group)
9
Q
Net proton secretion
A
acidifies bile–> decrease precipitation Ca2+ salts –> less gall stones
10
Q
Motillin
A
M cells
stimuls: neural fasting
1st target: upper GI motility
