Fat processing

Question 1

omega 3/6

Answer 1

precursors for inflammatory (esp. o6 which –> arachidonic acid) and anti-inflammatory molecules

Question 2

Chylomicrons

Answer 2

from intestine to blood

Question 3

oxidation of FA

Answer 3

FA–> acetyl CoA (cytosol)
Beta oxidation in mitochondria= spiral process, releases NADH, FADH2 and a CoA. Can require carnitine transport, controlled by conc of malonyl CoA- inhibits enzyme

Question 4

Ketone bodies

Answer 4

from excess CoA in mitochondria

eg. acetone –> acetate= pear drop breath

Question 5

Cholesterol synthesis

Answer 5

acetyl CoA–> mevalonate–> phosphorylated isoprene –. squalene (C30) –> lanosterol (ring structure)–> cholesterol
1st stage= controls rate- activity of HMG CoA reductase- controlled by phosphorylation
in cytosol and SER